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The cellular response to plasma membrane disruption for nanomaterial delivery
Delivery of nanomaterials into cells is of interest for fundamental cell biological research as well as for therapeutic and diagnostic purposes. One way of doing so is by physically disrupting the plasma membrane (PM). Several methods that exploit electrical, mechanical or optical cues have been con...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807741/ https://www.ncbi.nlm.nih.gov/pubmed/35103909 http://dx.doi.org/10.1186/s40580-022-00298-7 |
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author | Houthaeve, Gaëlle De Smedt, Stefaan C. Braeckmans, Kevin De Vos, Winnok H. |
author_facet | Houthaeve, Gaëlle De Smedt, Stefaan C. Braeckmans, Kevin De Vos, Winnok H. |
author_sort | Houthaeve, Gaëlle |
collection | PubMed |
description | Delivery of nanomaterials into cells is of interest for fundamental cell biological research as well as for therapeutic and diagnostic purposes. One way of doing so is by physically disrupting the plasma membrane (PM). Several methods that exploit electrical, mechanical or optical cues have been conceived to temporarily disrupt the PM for intracellular delivery, with variable effects on cell viability. However, apart from acute cytotoxicity, subtler effects on cell physiology may occur as well. Their nature and timing vary with the severity of the insult and the efficiency of repair, but some may provoke permanent phenotypic alterations. With the growing palette of nanoscale delivery methods and applications, comes a need for an in-depth understanding of this cellular response. In this review, we summarize current knowledge about the chronology of cellular events that take place upon PM injury inflicted by different delivery methods. We also elaborate on their significance for cell homeostasis and cell fate. Based on the crucial nodes that govern cell fitness and functionality, we give directions for fine-tuning nano-delivery conditions. |
format | Online Article Text |
id | pubmed-8807741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-88077412022-02-02 The cellular response to plasma membrane disruption for nanomaterial delivery Houthaeve, Gaëlle De Smedt, Stefaan C. Braeckmans, Kevin De Vos, Winnok H. Nano Converg Review Delivery of nanomaterials into cells is of interest for fundamental cell biological research as well as for therapeutic and diagnostic purposes. One way of doing so is by physically disrupting the plasma membrane (PM). Several methods that exploit electrical, mechanical or optical cues have been conceived to temporarily disrupt the PM for intracellular delivery, with variable effects on cell viability. However, apart from acute cytotoxicity, subtler effects on cell physiology may occur as well. Their nature and timing vary with the severity of the insult and the efficiency of repair, but some may provoke permanent phenotypic alterations. With the growing palette of nanoscale delivery methods and applications, comes a need for an in-depth understanding of this cellular response. In this review, we summarize current knowledge about the chronology of cellular events that take place upon PM injury inflicted by different delivery methods. We also elaborate on their significance for cell homeostasis and cell fate. Based on the crucial nodes that govern cell fitness and functionality, we give directions for fine-tuning nano-delivery conditions. Springer Singapore 2022-02-01 /pmc/articles/PMC8807741/ /pubmed/35103909 http://dx.doi.org/10.1186/s40580-022-00298-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Houthaeve, Gaëlle De Smedt, Stefaan C. Braeckmans, Kevin De Vos, Winnok H. The cellular response to plasma membrane disruption for nanomaterial delivery |
title | The cellular response to plasma membrane disruption for nanomaterial delivery |
title_full | The cellular response to plasma membrane disruption for nanomaterial delivery |
title_fullStr | The cellular response to plasma membrane disruption for nanomaterial delivery |
title_full_unstemmed | The cellular response to plasma membrane disruption for nanomaterial delivery |
title_short | The cellular response to plasma membrane disruption for nanomaterial delivery |
title_sort | cellular response to plasma membrane disruption for nanomaterial delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807741/ https://www.ncbi.nlm.nih.gov/pubmed/35103909 http://dx.doi.org/10.1186/s40580-022-00298-7 |
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