The DNA methylome of cervical cells can predict the presence of ovarian cancer

The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from women with and without ovarian cancer (i.e. referred to as t...

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Autores principales: Barrett, James E., Jones, Allison, Evans, Iona, Reisel, Daniel, Herzog, Chiara, Chindera, Kantaraja, Kristiansen, Mark, Leavy, Olivia C., Manchanda, Ranjit, Bjørge, Line, Zikan, Michal, Cibula, David, Widschwendter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807742/
https://www.ncbi.nlm.nih.gov/pubmed/35105887
http://dx.doi.org/10.1038/s41467-021-26615-y
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author Barrett, James E.
Jones, Allison
Evans, Iona
Reisel, Daniel
Herzog, Chiara
Chindera, Kantaraja
Kristiansen, Mark
Leavy, Olivia C.
Manchanda, Ranjit
Bjørge, Line
Zikan, Michal
Cibula, David
Widschwendter, Martin
author_facet Barrett, James E.
Jones, Allison
Evans, Iona
Reisel, Daniel
Herzog, Chiara
Chindera, Kantaraja
Kristiansen, Mark
Leavy, Olivia C.
Manchanda, Ranjit
Bjørge, Line
Zikan, Michal
Cibula, David
Widschwendter, Martin
author_sort Barrett, James E.
collection PubMed
description The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from women with and without ovarian cancer (i.e. referred to as the Women’s risk IDentification for Ovarian Cancer index or WID-OC-index) is capable of identifying women with an ovarian cancer in the absence of tumour DNA with an AUC of 0.76 and women with an endometrial cancer with an AUC of 0.81. This and the observation that the cervical cell WID-OC-index mimics the epigenetic program of those cells at risk of becoming cancerous in BRCA1/2 germline mutation carriers (i.e. mammary epithelium, fallopian tube fimbriae, prostate) further suggest that the epigenetic misprogramming of cervical cells is an indicator for cancer predisposition. This concept has the potential to advance the field of risk-stratified cancer screening and prevention.
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spelling pubmed-88077422022-02-07 The DNA methylome of cervical cells can predict the presence of ovarian cancer Barrett, James E. Jones, Allison Evans, Iona Reisel, Daniel Herzog, Chiara Chindera, Kantaraja Kristiansen, Mark Leavy, Olivia C. Manchanda, Ranjit Bjørge, Line Zikan, Michal Cibula, David Widschwendter, Martin Nat Commun Article The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from women with and without ovarian cancer (i.e. referred to as the Women’s risk IDentification for Ovarian Cancer index or WID-OC-index) is capable of identifying women with an ovarian cancer in the absence of tumour DNA with an AUC of 0.76 and women with an endometrial cancer with an AUC of 0.81. This and the observation that the cervical cell WID-OC-index mimics the epigenetic program of those cells at risk of becoming cancerous in BRCA1/2 germline mutation carriers (i.e. mammary epithelium, fallopian tube fimbriae, prostate) further suggest that the epigenetic misprogramming of cervical cells is an indicator for cancer predisposition. This concept has the potential to advance the field of risk-stratified cancer screening and prevention. Nature Publishing Group UK 2022-02-01 /pmc/articles/PMC8807742/ /pubmed/35105887 http://dx.doi.org/10.1038/s41467-021-26615-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Barrett, James E.
Jones, Allison
Evans, Iona
Reisel, Daniel
Herzog, Chiara
Chindera, Kantaraja
Kristiansen, Mark
Leavy, Olivia C.
Manchanda, Ranjit
Bjørge, Line
Zikan, Michal
Cibula, David
Widschwendter, Martin
The DNA methylome of cervical cells can predict the presence of ovarian cancer
title The DNA methylome of cervical cells can predict the presence of ovarian cancer
title_full The DNA methylome of cervical cells can predict the presence of ovarian cancer
title_fullStr The DNA methylome of cervical cells can predict the presence of ovarian cancer
title_full_unstemmed The DNA methylome of cervical cells can predict the presence of ovarian cancer
title_short The DNA methylome of cervical cells can predict the presence of ovarian cancer
title_sort dna methylome of cervical cells can predict the presence of ovarian cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807742/
https://www.ncbi.nlm.nih.gov/pubmed/35105887
http://dx.doi.org/10.1038/s41467-021-26615-y
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