Cargando…
Hippocampus and its involvement in Alzheimer’s disease: a review
Hippocampus is the significant component of the limbic lobe, which is further subdivided into the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for learning and memory; its sub-regions aid in the generation of episodic memory. However, the hippocampus is one of the brain areas a...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807768/ https://www.ncbi.nlm.nih.gov/pubmed/35116217 http://dx.doi.org/10.1007/s13205-022-03123-4 |
_version_ | 1784643752363556864 |
---|---|
author | Rao, Y. Lakshmisha Ganaraja, B. Murlimanju, B. V. Joy, Teresa Krishnamurthy, Ashwin Agrawal, Amit |
author_facet | Rao, Y. Lakshmisha Ganaraja, B. Murlimanju, B. V. Joy, Teresa Krishnamurthy, Ashwin Agrawal, Amit |
author_sort | Rao, Y. Lakshmisha |
collection | PubMed |
description | Hippocampus is the significant component of the limbic lobe, which is further subdivided into the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for learning and memory; its sub-regions aid in the generation of episodic memory. However, the hippocampus is one of the brain areas affected by Alzheimer’s (AD). In the early stages of AD, the hippocampus shows rapid loss of its tissue, which is associated with the functional disconnection with other parts of the brain. In the progression of AD, atrophy of medial temporal and hippocampal regions are the structural markers in magnetic resonance imaging (MRI). Lack of sirtuin (SIRT) expression in the hippocampal neurons will impair cognitive function, including recent memory and spatial learning. Proliferation, differentiation, and migrations are the steps involved in adult neurogenesis. The microglia in the hippocampal region are more immunologically active than the other regions of the brain. Intrinsic factors like hormones, glia, and vascular nourishment are instrumental in the neural stem cell (NSC) functions by maintaining the brain’s microenvironment. Along with the intrinsic factors, many extrinsic factors like dietary intake and physical activity may also influence the NSCs. Hence, pro-neurogenic lifestyle could delay neurodegeneration. |
format | Online Article Text |
id | pubmed-8807768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88077682022-02-02 Hippocampus and its involvement in Alzheimer’s disease: a review Rao, Y. Lakshmisha Ganaraja, B. Murlimanju, B. V. Joy, Teresa Krishnamurthy, Ashwin Agrawal, Amit 3 Biotech Review Article Hippocampus is the significant component of the limbic lobe, which is further subdivided into the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for learning and memory; its sub-regions aid in the generation of episodic memory. However, the hippocampus is one of the brain areas affected by Alzheimer’s (AD). In the early stages of AD, the hippocampus shows rapid loss of its tissue, which is associated with the functional disconnection with other parts of the brain. In the progression of AD, atrophy of medial temporal and hippocampal regions are the structural markers in magnetic resonance imaging (MRI). Lack of sirtuin (SIRT) expression in the hippocampal neurons will impair cognitive function, including recent memory and spatial learning. Proliferation, differentiation, and migrations are the steps involved in adult neurogenesis. The microglia in the hippocampal region are more immunologically active than the other regions of the brain. Intrinsic factors like hormones, glia, and vascular nourishment are instrumental in the neural stem cell (NSC) functions by maintaining the brain’s microenvironment. Along with the intrinsic factors, many extrinsic factors like dietary intake and physical activity may also influence the NSCs. Hence, pro-neurogenic lifestyle could delay neurodegeneration. Springer International Publishing 2022-02-01 2022-02 /pmc/articles/PMC8807768/ /pubmed/35116217 http://dx.doi.org/10.1007/s13205-022-03123-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Rao, Y. Lakshmisha Ganaraja, B. Murlimanju, B. V. Joy, Teresa Krishnamurthy, Ashwin Agrawal, Amit Hippocampus and its involvement in Alzheimer’s disease: a review |
title | Hippocampus and its involvement in Alzheimer’s disease: a review |
title_full | Hippocampus and its involvement in Alzheimer’s disease: a review |
title_fullStr | Hippocampus and its involvement in Alzheimer’s disease: a review |
title_full_unstemmed | Hippocampus and its involvement in Alzheimer’s disease: a review |
title_short | Hippocampus and its involvement in Alzheimer’s disease: a review |
title_sort | hippocampus and its involvement in alzheimer’s disease: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807768/ https://www.ncbi.nlm.nih.gov/pubmed/35116217 http://dx.doi.org/10.1007/s13205-022-03123-4 |
work_keys_str_mv | AT raoylakshmisha hippocampusanditsinvolvementinalzheimersdiseaseareview AT ganarajab hippocampusanditsinvolvementinalzheimersdiseaseareview AT murlimanjubv hippocampusanditsinvolvementinalzheimersdiseaseareview AT joyteresa hippocampusanditsinvolvementinalzheimersdiseaseareview AT krishnamurthyashwin hippocampusanditsinvolvementinalzheimersdiseaseareview AT agrawalamit hippocampusanditsinvolvementinalzheimersdiseaseareview |