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What is paradoxical lucidity? The answer begins with its definition
Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A provisional definition was proposed by the 2018 National Institute on Aging expert workshop and published in Alzheimer's and Dementia. However, several conceptual features of this definition remain vague...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807788/ https://www.ncbi.nlm.nih.gov/pubmed/34338400 http://dx.doi.org/10.1002/alz.12424 |
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author | Peterson, Andrew Clapp, Justin Largent, Emily A. Harkins, Kristin Stites, Shana D. Karlawish, Jason |
author_facet | Peterson, Andrew Clapp, Justin Largent, Emily A. Harkins, Kristin Stites, Shana D. Karlawish, Jason |
author_sort | Peterson, Andrew |
collection | PubMed |
description | Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A provisional definition was proposed by the 2018 National Institute on Aging expert workshop and published in Alzheimer's and Dementia. However, several conceptual features of this definition remain vague, creating barriers to robust clinical research. Here, we critically analyze the provisional definition and present a refined definition that can be applied in clinical research. The refined definition is based on an analytic process our research group recently undertook to operationalize paradoxical lucidity for our own study protocol. Our goal is to facilitate debate and potentially harmonize interpretations of paradoxical lucidity among research groups. |
format | Online Article Text |
id | pubmed-8807788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88077882022-10-14 What is paradoxical lucidity? The answer begins with its definition Peterson, Andrew Clapp, Justin Largent, Emily A. Harkins, Kristin Stites, Shana D. Karlawish, Jason Alzheimers Dement Perspective Paradoxical lucidity in dementia is a clinically significant but understudied phenomenon. A provisional definition was proposed by the 2018 National Institute on Aging expert workshop and published in Alzheimer's and Dementia. However, several conceptual features of this definition remain vague, creating barriers to robust clinical research. Here, we critically analyze the provisional definition and present a refined definition that can be applied in clinical research. The refined definition is based on an analytic process our research group recently undertook to operationalize paradoxical lucidity for our own study protocol. Our goal is to facilitate debate and potentially harmonize interpretations of paradoxical lucidity among research groups. John Wiley and Sons Inc. 2021-08-02 2022-03 /pmc/articles/PMC8807788/ /pubmed/34338400 http://dx.doi.org/10.1002/alz.12424 Text en © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Perspective Peterson, Andrew Clapp, Justin Largent, Emily A. Harkins, Kristin Stites, Shana D. Karlawish, Jason What is paradoxical lucidity? The answer begins with its definition |
title | What is paradoxical lucidity? The answer begins with its definition |
title_full | What is paradoxical lucidity? The answer begins with its definition |
title_fullStr | What is paradoxical lucidity? The answer begins with its definition |
title_full_unstemmed | What is paradoxical lucidity? The answer begins with its definition |
title_short | What is paradoxical lucidity? The answer begins with its definition |
title_sort | what is paradoxical lucidity? the answer begins with its definition |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807788/ https://www.ncbi.nlm.nih.gov/pubmed/34338400 http://dx.doi.org/10.1002/alz.12424 |
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