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Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity

In obesity, signaling through the IRE1 arm of the unfolded protein response exerts both protective and harmful effects. Overexpression of the IRE1-regulated transcription factor XBP1s in liver or fat protects against obesity-linked metabolic deterioration. However, hyperactivation of IRE1 engages re...

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Detalles Bibliográficos
Autores principales:	Madhavan, Aparajita, Kok, Bernard P., Rius, Bibiana, Grandjean, Julia M. D., Alabi, Adekunle, Albert, Verena, Sukiasyan, Ara, Powers, Evan T., Galmozzi, Andrea, Saez, Enrique, Wiseman, R. Luke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807832/ https://www.ncbi.nlm.nih.gov/pubmed/35105890 http://dx.doi.org/10.1038/s41467-022-28271-2

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