Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors

Retinitis pigmentosa is characterized by a dysregulation within the metabolic coupling of the retina, particularly between the glycolytic photoreceptors and the oxidative retina pigment epithelium. This phenomenon of metabolic uncoupling is seen in both aging and retinal degenerative diseases, as we...

Descripción completa

Detalles Bibliográficos
Autores principales: Nolan, Nicholas D., Caruso, Salvatore Marco, Cui, Xuan, Tsang, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807833/
https://www.ncbi.nlm.nih.gov/pubmed/34974542
http://dx.doi.org/10.1038/s41433-021-01726-4
_version_ 1784643761208295424
author Nolan, Nicholas D.
Caruso, Salvatore Marco
Cui, Xuan
Tsang, Stephen H.
author_facet Nolan, Nicholas D.
Caruso, Salvatore Marco
Cui, Xuan
Tsang, Stephen H.
author_sort Nolan, Nicholas D.
collection PubMed
description Retinitis pigmentosa is characterized by a dysregulation within the metabolic coupling of the retina, particularly between the glycolytic photoreceptors and the oxidative retina pigment epithelium. This phenomenon of metabolic uncoupling is seen in both aging and retinal degenerative diseases, as well as across a variety of cell types in human biology. Given its crucial role in the health and maintenance of these cell types, the metabolic pathways involved present a suitable area for therapeutic intervention. Herein, this review covers the scope of this delicate metabolic interplay, its dysregulation, how it relates to the retina as well other cell types, and finally concludes with a summary of various strategies aimed at reinstating normal metabolic coupling within the retina, and future directions within the field.
format Online
Article
Text
id pubmed-8807833
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-88078332022-02-07 Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors Nolan, Nicholas D. Caruso, Salvatore Marco Cui, Xuan Tsang, Stephen H. Eye (Lond) Review Article Retinitis pigmentosa is characterized by a dysregulation within the metabolic coupling of the retina, particularly between the glycolytic photoreceptors and the oxidative retina pigment epithelium. This phenomenon of metabolic uncoupling is seen in both aging and retinal degenerative diseases, as well as across a variety of cell types in human biology. Given its crucial role in the health and maintenance of these cell types, the metabolic pathways involved present a suitable area for therapeutic intervention. Herein, this review covers the scope of this delicate metabolic interplay, its dysregulation, how it relates to the retina as well other cell types, and finally concludes with a summary of various strategies aimed at reinstating normal metabolic coupling within the retina, and future directions within the field. Nature Publishing Group UK 2022-01-01 2022-02 /pmc/articles/PMC8807833/ /pubmed/34974542 http://dx.doi.org/10.1038/s41433-021-01726-4 Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Nolan, Nicholas D.
Caruso, Salvatore Marco
Cui, Xuan
Tsang, Stephen H.
Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
title Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
title_full Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
title_fullStr Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
title_full_unstemmed Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
title_short Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
title_sort renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative rpe niche fuels the more glycolytic photoreceptors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807833/
https://www.ncbi.nlm.nih.gov/pubmed/34974542
http://dx.doi.org/10.1038/s41433-021-01726-4
work_keys_str_mv AT nolannicholasd renormalizationofmetaboliccouplingtreatsagerelateddegenerativedisordersanoxidativerpenichefuelsthemoreglycolyticphotoreceptors
AT carusosalvatoremarco renormalizationofmetaboliccouplingtreatsagerelateddegenerativedisordersanoxidativerpenichefuelsthemoreglycolyticphotoreceptors
AT cuixuan renormalizationofmetaboliccouplingtreatsagerelateddegenerativedisordersanoxidativerpenichefuelsthemoreglycolyticphotoreceptors
AT tsangstephenh renormalizationofmetaboliccouplingtreatsagerelateddegenerativedisordersanoxidativerpenichefuelsthemoreglycolyticphotoreceptors

Ejemplares similares