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Inhibition of base editors with anti-deaminases derived from viruses

Cytosine base editors (CBEs), combining cytidine deaminases with the Cas9 nickase (nCas9), enable targeted C-to-T conversions in genomic DNA and are powerful genome-editing tools used in biotechnology and medicine. However, the overexpression of cytidine deaminases in vivo leads to unexpected potent...

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Detalles Bibliográficos
Autores principales:	Liu, Zhiquan, Chen, Siyu, Lai, Liangxue, Li, Zhanjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807840/ https://www.ncbi.nlm.nih.gov/pubmed/35105899 http://dx.doi.org/10.1038/s41467-022-28300-0

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