Novel insights into the interaction between N6-methyladenosine modification and circular RNA

As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently c...

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Detalles Bibliográficos
Autores principales: Xu, Tao, He, Bangshun, Sun, Huiling, Xiong, Mengqiu, Nie, Junjie, Wang, Shukui, Pan, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807973/
https://www.ncbi.nlm.nih.gov/pubmed/35141044
http://dx.doi.org/10.1016/j.omtn.2022.01.007
Descripción
Sumario:As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently closed loop structure, play an essential role in various physiological and pathological processes. Extensive studies have revealed that m(6)A modification is widespread in circRNAs and influences their biogenesis and functions. Intriguingly, circRNAs can affect m(6)A modification by regulating m(6)A regulatory proteins. In this review, we summarize the characteristics and biological functions of m(6)A and circRNAs and focus on recent advances in the interaction of m(6)A modification and circRNAs. In addition, the potential clinical applications of m(6)A modification and circRNAs in diagnosis and therapeutic targets are discussed.

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