Novel insights into the interaction between N6-methyladenosine modification and circular RNA

As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently c...

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Autores principales: Xu, Tao, He, Bangshun, Sun, Huiling, Xiong, Mengqiu, Nie, Junjie, Wang, Shukui, Pan, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807973/
https://www.ncbi.nlm.nih.gov/pubmed/35141044
http://dx.doi.org/10.1016/j.omtn.2022.01.007
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author Xu, Tao
He, Bangshun
Sun, Huiling
Xiong, Mengqiu
Nie, Junjie
Wang, Shukui
Pan, Yuqin
author_facet Xu, Tao
He, Bangshun
Sun, Huiling
Xiong, Mengqiu
Nie, Junjie
Wang, Shukui
Pan, Yuqin
author_sort Xu, Tao
collection PubMed
description As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently closed loop structure, play an essential role in various physiological and pathological processes. Extensive studies have revealed that m(6)A modification is widespread in circRNAs and influences their biogenesis and functions. Intriguingly, circRNAs can affect m(6)A modification by regulating m(6)A regulatory proteins. In this review, we summarize the characteristics and biological functions of m(6)A and circRNAs and focus on recent advances in the interaction of m(6)A modification and circRNAs. In addition, the potential clinical applications of m(6)A modification and circRNAs in diagnosis and therapeutic targets are discussed.
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spelling pubmed-88079732022-02-08 Novel insights into the interaction between N6-methyladenosine modification and circular RNA Xu, Tao He, Bangshun Sun, Huiling Xiong, Mengqiu Nie, Junjie Wang, Shukui Pan, Yuqin Mol Ther Nucleic Acids Review As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m(6)A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently closed loop structure, play an essential role in various physiological and pathological processes. Extensive studies have revealed that m(6)A modification is widespread in circRNAs and influences their biogenesis and functions. Intriguingly, circRNAs can affect m(6)A modification by regulating m(6)A regulatory proteins. In this review, we summarize the characteristics and biological functions of m(6)A and circRNAs and focus on recent advances in the interaction of m(6)A modification and circRNAs. In addition, the potential clinical applications of m(6)A modification and circRNAs in diagnosis and therapeutic targets are discussed. American Society of Gene & Cell Therapy 2022-01-10 /pmc/articles/PMC8807973/ /pubmed/35141044 http://dx.doi.org/10.1016/j.omtn.2022.01.007 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Xu, Tao
He, Bangshun
Sun, Huiling
Xiong, Mengqiu
Nie, Junjie
Wang, Shukui
Pan, Yuqin
Novel insights into the interaction between N6-methyladenosine modification and circular RNA
title Novel insights into the interaction between N6-methyladenosine modification and circular RNA
title_full Novel insights into the interaction between N6-methyladenosine modification and circular RNA
title_fullStr Novel insights into the interaction between N6-methyladenosine modification and circular RNA
title_full_unstemmed Novel insights into the interaction between N6-methyladenosine modification and circular RNA
title_short Novel insights into the interaction between N6-methyladenosine modification and circular RNA
title_sort novel insights into the interaction between n6-methyladenosine modification and circular rna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807973/
https://www.ncbi.nlm.nih.gov/pubmed/35141044
http://dx.doi.org/10.1016/j.omtn.2022.01.007
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