Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation

Urocortin-2 (Ucn-2) has demonstrated cardioprotective actions against myocardial ischemia-reperfusion (I/R) injuries. Herein, we explored the protective role of Ucn-2 through microRNAs (miRNAs) post-transcriptional regulation of apoptotic and pro-fibrotic genes. We determined that the intravenous ad...

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Detalles Bibliográficos
Autores principales: Mayoral-González, Isabel, Calderón-Sánchez, Eva M., Galeano-Otero, Isabel, Martín-Bórnez, Marta, Gutiérrez-Carretero, Encarnación, Fernández-Velasco, María, Domenech, Nieves, Crespo-Leiro, María Generosa, Gómez, Ana María, Ordóñez-Fernández, Antonio, Hmadcha, Abdelkrim, Smani, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807986/
https://www.ncbi.nlm.nih.gov/pubmed/35141045
http://dx.doi.org/10.1016/j.omtn.2022.01.003

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