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KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block

Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized tre...

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Autores principales: Garcia-Robledo, Juan Esteban, Rosell, Rafael, Ruíz-Patiño, Alejandro, Sotelo, Carolina, Arrieta, Oscar, Zatarain-Barrón, Lucia, Ordoñez, Camila, Jaller, Elvira, Rojas, Leonardo, Russo, Alessandro, de Miguel-Pérez, Diego, Rolfo, Christian, Cardona, Andrés F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808025/
https://www.ncbi.nlm.nih.gov/pubmed/35098800
http://dx.doi.org/10.1177/17534666211066064
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author Garcia-Robledo, Juan Esteban
Rosell, Rafael
Ruíz-Patiño, Alejandro
Sotelo, Carolina
Arrieta, Oscar
Zatarain-Barrón, Lucia
Ordoñez, Camila
Jaller, Elvira
Rojas, Leonardo
Russo, Alessandro
de Miguel-Pérez, Diego
Rolfo, Christian
Cardona, Andrés F.
author_facet Garcia-Robledo, Juan Esteban
Rosell, Rafael
Ruíz-Patiño, Alejandro
Sotelo, Carolina
Arrieta, Oscar
Zatarain-Barrón, Lucia
Ordoñez, Camila
Jaller, Elvira
Rojas, Leonardo
Russo, Alessandro
de Miguel-Pérez, Diego
Rolfo, Christian
Cardona, Andrés F.
author_sort Garcia-Robledo, Juan Esteban
collection PubMed
description Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized treatment based on the tumor’s molecular genomics. This review presents a comprehensive review of the biology, new therapeutic interventions, and resistance patterns of two well-defined subgroups, tumors with KRAS and MET alterations. We also discuss the status of molecular testing practices for these two key oncogenic drivers, considering the progressive introduction of next-generation sequencing (NGS) and RNA sequencing in regular clinical practice.
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spelling pubmed-88080252022-02-03 KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block Garcia-Robledo, Juan Esteban Rosell, Rafael Ruíz-Patiño, Alejandro Sotelo, Carolina Arrieta, Oscar Zatarain-Barrón, Lucia Ordoñez, Camila Jaller, Elvira Rojas, Leonardo Russo, Alessandro de Miguel-Pérez, Diego Rolfo, Christian Cardona, Andrés F. Ther Adv Respir Dis Review Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized treatment based on the tumor’s molecular genomics. This review presents a comprehensive review of the biology, new therapeutic interventions, and resistance patterns of two well-defined subgroups, tumors with KRAS and MET alterations. We also discuss the status of molecular testing practices for these two key oncogenic drivers, considering the progressive introduction of next-generation sequencing (NGS) and RNA sequencing in regular clinical practice. SAGE Publications 2022-01-31 /pmc/articles/PMC8808025/ /pubmed/35098800 http://dx.doi.org/10.1177/17534666211066064 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Garcia-Robledo, Juan Esteban
Rosell, Rafael
Ruíz-Patiño, Alejandro
Sotelo, Carolina
Arrieta, Oscar
Zatarain-Barrón, Lucia
Ordoñez, Camila
Jaller, Elvira
Rojas, Leonardo
Russo, Alessandro
de Miguel-Pérez, Diego
Rolfo, Christian
Cardona, Andrés F.
KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
title KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
title_full KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
title_fullStr KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
title_full_unstemmed KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
title_short KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
title_sort kras and met in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808025/
https://www.ncbi.nlm.nih.gov/pubmed/35098800
http://dx.doi.org/10.1177/17534666211066064
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