Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903

Nonsense mutations, which occur in ∼11% of patients with genetic disorders, introduce premature termination codons (PTCs) that lead to truncated proteins and promote nonsense-mediated mRNA decay. Aminoglycosides such as G418 permit PTC readthrough and so may be used to address this problem. However,...

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Detalles Bibliográficos
Autores principales: Baradaran-Heravi, Alireza, Bauer, Claudia C., Pickles, Isabelle B., Hosseini-Farahabadi, Sara, Balgi, Aruna D., Choi, Kunho, Linley, Deborah M., Beech, David J., Roberge, Michel, Bon, Robin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808171/
https://www.ncbi.nlm.nih.gov/pubmed/34999117
http://dx.doi.org/10.1016/j.jbc.2021.101546

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