Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

The glucocorticoid (GC) receptor (GR) is essential for normal development and in the initiation of inflammation. Healthy GR(dim/dim) mice with reduced dimerization propensity due to a point mutation (A465T) at the dimer interface of the GR DNA-binding domain (DBD) (here GR(D/D)) have previously help...

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Detalles Bibliográficos
Autores principales: Timmermans, Steven, Verhoog, Nicolette J.D., Van Looveren, Kelly, Dewaele, Sylviane, Hochepied, Tino, Eggermont, Melanie, Gilbert, Barbara, Boerema-de Munck, Anne, Vanderhaeghen, Tineke, Vanden Berghe, Joke, Garcia Gonzalez, Natalia, Vandewalle, Jolien, Bloch, Yehudi, Provost, Mathias, Savvides, Savvas N., De Bosscher, Karolien, Declercq, Wim, Rottier, Robbert J., Louw, Ann, Libert, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808175/
https://www.ncbi.nlm.nih.gov/pubmed/35007536
http://dx.doi.org/10.1016/j.jbc.2022.101574

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