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Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

The mitochondrial pyruvate carrier (MPC) is an inner mitochondrial membrane complex that plays a critical role in intermediary metabolism. Inhibition of the MPC, especially in liver, may have efficacy for treating type 2 diabetes mellitus. Herein, we examined the antidiabetic effects of zaprinast an...

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Detalles Bibliográficos
Autores principales:	Hodges, Wesley T., Jarasvaraparn, Chaowapong, Ferguson, Daniel, Griffett, Kristine, Gill, Lauren E., Chen, Yana, Ilagan, Ma. Xenia G., Hegazy, Lamees, Elgendy, Bahaa, Cho, Kevin, Patti, Gary J., McCommis, Kyle S., Finck, Brian N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808181/ https://www.ncbi.nlm.nih.gov/pubmed/34973337 http://dx.doi.org/10.1016/j.jbc.2021.101554

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