Cargando…

Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis

BACKGROUND: The aim of our study was to detect the rate of unexplained total fertilization failure (TFF) after intracytoplasmic sperm injection (ICSI) and identify its risk factors and retreatment prognosis. MATERIALS AND METHODS: In this retrospective case-control study, we searched the computerize...

Descripción completa

Detalles Bibliográficos
Autores principales: Mostafaei, Parisa, Ghaffari, Firouzeh, Zolfaghari, Zahra, Vesali, Samira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808256/
https://www.ncbi.nlm.nih.gov/pubmed/35103431
http://dx.doi.org/10.22074/IJFS.2021.138468.1036
_version_ 1784643848622833664
author Mostafaei, Parisa
Ghaffari, Firouzeh
Zolfaghari, Zahra
Vesali, Samira
author_facet Mostafaei, Parisa
Ghaffari, Firouzeh
Zolfaghari, Zahra
Vesali, Samira
author_sort Mostafaei, Parisa
collection PubMed
description BACKGROUND: The aim of our study was to detect the rate of unexplained total fertilization failure (TFF) after intracytoplasmic sperm injection (ICSI) and identify its risk factors and retreatment prognosis. MATERIALS AND METHODS: In this retrospective case-control study, we searched the computerized database of the Royan Institute (Tehran, Iran) from March 2015 to March 2019 and retrieved all cases diagnosed with TFF after ICSI. TFF cases that did not have any recognized risk factors were classified as unexplained (subgroup A). Cases with recognized risk factors were classified as subgroup B. The control group was randomly selected from infertile couples who underwent ICSI cycles with fertilization of at least one oocyte during the same time interval. Characteristics and treatment outcomes of the cases with unexplained TFF (subgroup A) were compared to the control group, and to the other TFF cases (subgroup B). RESULTS: Out of 18,750 couples who underwent ICSI cycles, 296 (1.58%) experienced TFF for the first time. Of these, 49 (16.5%) couples were diagnosed as unexplained TFF (subgroup A) and 247 (83.5%) were placed in subgroup B, TFF with expected risk factors. Multivariable logistic regression analysis showed that the total number of mature oocytes (P<0.001), duration of infertility (P=0.043), and women’s body mass index (BMI, P<0.001) were significant predictive factors for unexplained TFF. In the ICSI cycle after TFF, clinical pregnancy and live birth rates in subgroup A were higher than subgroup B. Although differences between these groups were not statistically significant (P=0.14 and P=0.07, respectively), this finding could be clinically important. CONCLUSION: Unexplained TFF following ICSI is a rare event significantly related to a lower number of mature oocytes, longer duration of infertility and higher female BMI. It has a good prognosis in retreatment cycles in comparison with expected TFF cases. Clinicians should take this into consideration for patient counseling and management.
format Online
Article
Text
id pubmed-8808256
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Royan Institute
record_format MEDLINE/PubMed
spelling pubmed-88082562022-05-02 Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis Mostafaei, Parisa Ghaffari, Firouzeh Zolfaghari, Zahra Vesali, Samira Int J Fertil Steril Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis BACKGROUND: The aim of our study was to detect the rate of unexplained total fertilization failure (TFF) after intracytoplasmic sperm injection (ICSI) and identify its risk factors and retreatment prognosis. MATERIALS AND METHODS: In this retrospective case-control study, we searched the computerized database of the Royan Institute (Tehran, Iran) from March 2015 to March 2019 and retrieved all cases diagnosed with TFF after ICSI. TFF cases that did not have any recognized risk factors were classified as unexplained (subgroup A). Cases with recognized risk factors were classified as subgroup B. The control group was randomly selected from infertile couples who underwent ICSI cycles with fertilization of at least one oocyte during the same time interval. Characteristics and treatment outcomes of the cases with unexplained TFF (subgroup A) were compared to the control group, and to the other TFF cases (subgroup B). RESULTS: Out of 18,750 couples who underwent ICSI cycles, 296 (1.58%) experienced TFF for the first time. Of these, 49 (16.5%) couples were diagnosed as unexplained TFF (subgroup A) and 247 (83.5%) were placed in subgroup B, TFF with expected risk factors. Multivariable logistic regression analysis showed that the total number of mature oocytes (P<0.001), duration of infertility (P=0.043), and women’s body mass index (BMI, P<0.001) were significant predictive factors for unexplained TFF. In the ICSI cycle after TFF, clinical pregnancy and live birth rates in subgroup A were higher than subgroup B. Although differences between these groups were not statistically significant (P=0.14 and P=0.07, respectively), this finding could be clinically important. CONCLUSION: Unexplained TFF following ICSI is a rare event significantly related to a lower number of mature oocytes, longer duration of infertility and higher female BMI. It has a good prognosis in retreatment cycles in comparison with expected TFF cases. Clinicians should take this into consideration for patient counseling and management. Royan Institute 2022 2022-01-17 /pmc/articles/PMC8808256/ /pubmed/35103431 http://dx.doi.org/10.22074/IJFS.2021.138468.1036 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited. https://creativecommons.org/licenses/by-nc/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 3.0 (CC BY-NC 3.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
Mostafaei, Parisa
Ghaffari, Firouzeh
Zolfaghari, Zahra
Vesali, Samira
Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
title Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
title_full Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
title_fullStr Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
title_full_unstemmed Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
title_short Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
title_sort unexplained total fertilization failure after intracytoplasmic sperm injection cycles: a case-control study on predictive factors and retreatment prognosis
topic Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808256/
https://www.ncbi.nlm.nih.gov/pubmed/35103431
http://dx.doi.org/10.22074/IJFS.2021.138468.1036
work_keys_str_mv AT mostafaeiparisa unexplainedtotalfertilizationfailureafterintracytoplasmicsperminjectioncyclesacasecontrolstudyonpredictivefactorsandretreatmentprognosis
AT ghaffarifirouzeh unexplainedtotalfertilizationfailureafterintracytoplasmicsperminjectioncyclesacasecontrolstudyonpredictivefactorsandretreatmentprognosis
AT zolfagharizahra unexplainedtotalfertilizationfailureafterintracytoplasmicsperminjectioncyclesacasecontrolstudyonpredictivefactorsandretreatmentprognosis
AT vesalisamira unexplainedtotalfertilizationfailureafterintracytoplasmicsperminjectioncyclesacasecontrolstudyonpredictivefactorsandretreatmentprognosis