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Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration

Bone defects are a common challenge in the clinical setting. Bone tissue engineering (BTE) is an effective treatment for the clinical problem of large bone defects. In this study, we fabricated silk fibroin (SF)/hydroxyapatite (HAp) scaffolds inlaid with naringin poly lactic-co-glycolic acid (PLGA)...

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Autores principales: Zhao, Zhi-hu, Ma, Xin-long, Ma, Jian-xiong, Kang, Jia-yu, Zhang, Yang, Guo, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808263/
https://www.ncbi.nlm.nih.gov/pubmed/35128373
http://dx.doi.org/10.1016/j.mtbio.2022.100206
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author Zhao, Zhi-hu
Ma, Xin-long
Ma, Jian-xiong
Kang, Jia-yu
Zhang, Yang
Guo, Yue
author_facet Zhao, Zhi-hu
Ma, Xin-long
Ma, Jian-xiong
Kang, Jia-yu
Zhang, Yang
Guo, Yue
author_sort Zhao, Zhi-hu
collection PubMed
description Bone defects are a common challenge in the clinical setting. Bone tissue engineering (BTE) is an effective treatment for the clinical problem of large bone defects. In this study, we fabricated silk fibroin (SF)/hydroxyapatite (HAp) scaffolds inlaid with naringin poly lactic-co-glycolic acid (PLGA) microspheres, investigating the feasibility of their application in BTE. Naringin PLGA microspheres were manufactured and adhered to the SF/HAp scaffold. Bone mesenchymal stem cells (BMSCs) were inoculated onto the SF/HAp scaffold containing naringin PLGA microsphere to examine the biocompatibility of the SF/HAp scaffolds. A rabbit femoral distal bone defect model was used to evaluate the in vivo function of the SF/HAp scaffolds containing naringin-loaded PLGA microspheres. The current study demonstrated that SF/HAp scaffolds containing naringin-loaded PLGA microspheres show promise as osteo-modulatory biomaterials for bone regeneration.
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spelling pubmed-88082632022-02-04 Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration Zhao, Zhi-hu Ma, Xin-long Ma, Jian-xiong Kang, Jia-yu Zhang, Yang Guo, Yue Mater Today Bio Full Length Article Bone defects are a common challenge in the clinical setting. Bone tissue engineering (BTE) is an effective treatment for the clinical problem of large bone defects. In this study, we fabricated silk fibroin (SF)/hydroxyapatite (HAp) scaffolds inlaid with naringin poly lactic-co-glycolic acid (PLGA) microspheres, investigating the feasibility of their application in BTE. Naringin PLGA microspheres were manufactured and adhered to the SF/HAp scaffold. Bone mesenchymal stem cells (BMSCs) were inoculated onto the SF/HAp scaffold containing naringin PLGA microsphere to examine the biocompatibility of the SF/HAp scaffolds. A rabbit femoral distal bone defect model was used to evaluate the in vivo function of the SF/HAp scaffolds containing naringin-loaded PLGA microspheres. The current study demonstrated that SF/HAp scaffolds containing naringin-loaded PLGA microspheres show promise as osteo-modulatory biomaterials for bone regeneration. Elsevier 2022-01-23 /pmc/articles/PMC8808263/ /pubmed/35128373 http://dx.doi.org/10.1016/j.mtbio.2022.100206 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Zhao, Zhi-hu
Ma, Xin-long
Ma, Jian-xiong
Kang, Jia-yu
Zhang, Yang
Guo, Yue
Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
title Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
title_full Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
title_fullStr Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
title_full_unstemmed Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
title_short Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
title_sort sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808263/
https://www.ncbi.nlm.nih.gov/pubmed/35128373
http://dx.doi.org/10.1016/j.mtbio.2022.100206
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