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The relationship between ageing and changes in the human blood and brain methylomes
Changes in DNA methylation have been found to be strongly correlated with age, enabling the creation of ‘epigenetic clocks’. Previously, studies on the relationship between ageing and DNA methylation have assumed a linear relationship. Here, we show that several markers show a non-linear behaviour....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808541/ https://www.ncbi.nlm.nih.gov/pubmed/35118376 http://dx.doi.org/10.1093/nargab/lqac001 |
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author | Bryant, Patrick Elofsson, Arne |
author_facet | Bryant, Patrick Elofsson, Arne |
author_sort | Bryant, Patrick |
collection | PubMed |
description | Changes in DNA methylation have been found to be strongly correlated with age, enabling the creation of ‘epigenetic clocks’. Previously, studies on the relationship between ageing and DNA methylation have assumed a linear relationship. Here, we show that several markers show a non-linear behaviour. In particular, we observe a tendency for saturation with age, especially in the cerebellum. Further, we show that the relationships between significant methylation changes and ageing are different in different tissues. We suggest a straightforward method of assessing all methylation-age relationships and cluster them according to their relative fold change. Our fold change selection outperforms the most common epigenetic clocks in predicting age for the cerebellum, but not for Blood or the Frontal Cortex. Further, we find that the saturation of methylation observed at older ages for the cerebellum explains why epigenetic clocks consistently underestimate the age there. The findings imply that assuming linear correlations might cause biologically important markers to be missed. |
format | Online Article Text |
id | pubmed-8808541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88085412022-02-02 The relationship between ageing and changes in the human blood and brain methylomes Bryant, Patrick Elofsson, Arne NAR Genom Bioinform Standard Article Changes in DNA methylation have been found to be strongly correlated with age, enabling the creation of ‘epigenetic clocks’. Previously, studies on the relationship between ageing and DNA methylation have assumed a linear relationship. Here, we show that several markers show a non-linear behaviour. In particular, we observe a tendency for saturation with age, especially in the cerebellum. Further, we show that the relationships between significant methylation changes and ageing are different in different tissues. We suggest a straightforward method of assessing all methylation-age relationships and cluster them according to their relative fold change. Our fold change selection outperforms the most common epigenetic clocks in predicting age for the cerebellum, but not for Blood or the Frontal Cortex. Further, we find that the saturation of methylation observed at older ages for the cerebellum explains why epigenetic clocks consistently underestimate the age there. The findings imply that assuming linear correlations might cause biologically important markers to be missed. Oxford University Press 2022-02-02 /pmc/articles/PMC8808541/ /pubmed/35118376 http://dx.doi.org/10.1093/nargab/lqac001 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Standard Article Bryant, Patrick Elofsson, Arne The relationship between ageing and changes in the human blood and brain methylomes |
title | The relationship between ageing and changes in the human blood and brain methylomes |
title_full | The relationship between ageing and changes in the human blood and brain methylomes |
title_fullStr | The relationship between ageing and changes in the human blood and brain methylomes |
title_full_unstemmed | The relationship between ageing and changes in the human blood and brain methylomes |
title_short | The relationship between ageing and changes in the human blood and brain methylomes |
title_sort | relationship between ageing and changes in the human blood and brain methylomes |
topic | Standard Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808541/ https://www.ncbi.nlm.nih.gov/pubmed/35118376 http://dx.doi.org/10.1093/nargab/lqac001 |
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