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Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease

BACKGROUND: Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of these glial cells but lack spatial information. We have developed a...

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Detalles Bibliográficos
Autores principales:	Muñoz-Castro, Clara, Noori, Ayush, Magdamo, Colin G., Li, Zhaozhi, Marks, Jordan D., Frosch, Matthew P., Das, Sudeshna, Hyman, Bradley T., Serrano-Pozo, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808995/ https://www.ncbi.nlm.nih.gov/pubmed/35109872 http://dx.doi.org/10.1186/s12974-022-02383-4

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