Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine liver combining single-cell CITE-seq, single-nuclei sequencing, spatial transcriptomics, and spatial proteomics. By int...

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Autores principales: Guilliams, Martin, Bonnardel, Johnny, Haest, Birthe, Vanderborght, Bart, Wagner, Camille, Remmerie, Anneleen, Bujko, Anna, Martens, Liesbet, Thoné, Tinne, Browaeys, Robin, De Ponti, Federico F., Vanneste, Bavo, Zwicker, Christian, Svedberg, Freya R., Vanhalewyn, Tineke, Gonçalves, Amanda, Lippens, Saskia, Devriendt, Bert, Cox, Eric, Ferrero, Giuliano, Wittamer, Valerie, Willaert, Andy, Kaptein, Suzanne J.F., Neyts, Johan, Dallmeier, Kai, Geldhof, Peter, Casaert, Stijn, Deplancke, Bart, ten Dijke, Peter, Hoorens, Anne, Vanlander, Aude, Berrevoet, Frederik, Van Nieuwenhove, Yves, Saeys, Yvan, Saelens, Wouter, Van Vlierberghe, Hans, Devisscher, Lindsey, Scott, Charlotte L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809252/
https://www.ncbi.nlm.nih.gov/pubmed/35021063
http://dx.doi.org/10.1016/j.cell.2021.12.018

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