RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4(+) T-cell-dependent antitumor immunity

Expanding the utility of immune-based cancer treatments is a clinical challenge due to tumor-intrinsic factors that suppress the immune response. Here we report the identification of tumoral Ring Finger Protein 2 (RNF2), the core subunit of the Polycomb Repressor Complex 1 (PRC1), as a negative regu...

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Detalles Bibliográficos
Autores principales: Zhang, Zhuo, Luo, Lin, Xing, Chuan, Chen, Yu, Xu, Peng, Li, Mao, Zeng, Ling, Li, Chao, Ghosh, Sadashib, Manna, Deborah Della, Townes, Tim, Britt, William J., Wajapeyee, Narendra, Sleckman, Barry P., Chong, Zechen, Wu Leavenworth, Jianmei, Yang, Eddy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809507/
https://www.ncbi.nlm.nih.gov/pubmed/35121884
http://dx.doi.org/10.1038/s43018-021-00263-z

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