Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis

Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular functions remain largely unknown. Here we show that the pseudouridine synthase PUS7 is highly expressed in glioblastoma versus normal brain tissues, and high PUS7 expression levels are associated with worse surv...

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Detalles Bibliográficos
Autores principales: Cui, Qi, Yin, Kailin, Zhang, Xiaoting, Ye, Peng, Chen, Xianwei, Chao, Jianfei, Meng, Haowei, Wei, Jiangbo, Daniel, Roeth, Li, Li, Qin, Yue, Sun, Guihua, Zhang, Mingzi, Klein, Jeremy, Huynhle, Marvin, Wang, Cheng, Zhang, Leying, Badie, Behnam, Kalkum, Markus, He, Chuan, Yi, Chengqi, Shi, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809511/
https://www.ncbi.nlm.nih.gov/pubmed/35121864
http://dx.doi.org/10.1038/s43018-021-00238-0

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