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Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021

BACKGROUND: Poor clinical adherence is the main factor that hinders ART adherence level in children and its ultimate effect on viral load suppression and decreasing morbidity and mortality of children. Although data from different settings are necessary to tackle such types of problems, the pieces o...

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Autores principales: Tiruneh, Chalie Marew, Emiru, Tigabu Desie, Tibebu, Nigusie Selomon, Abate, Moges Wubneh, Nigat, Adane Birhanu, Bantie, Berihun, Belete, Amsalu, Walle, Belete Gelaw, Legas, Getasew, Getu, Bisrat Dessie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809518/
https://www.ncbi.nlm.nih.gov/pubmed/35125892
http://dx.doi.org/10.2147/HIV.S352386
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author Tiruneh, Chalie Marew
Emiru, Tigabu Desie
Tibebu, Nigusie Selomon
Abate, Moges Wubneh
Nigat, Adane Birhanu
Bantie, Berihun
Belete, Amsalu
Walle, Belete Gelaw
Legas, Getasew
Getu, Bisrat Dessie
author_facet Tiruneh, Chalie Marew
Emiru, Tigabu Desie
Tibebu, Nigusie Selomon
Abate, Moges Wubneh
Nigat, Adane Birhanu
Bantie, Berihun
Belete, Amsalu
Walle, Belete Gelaw
Legas, Getasew
Getu, Bisrat Dessie
author_sort Tiruneh, Chalie Marew
collection PubMed
description BACKGROUND: Poor clinical adherence is the main factor that hinders ART adherence level in children and its ultimate effect on viral load suppression and decreasing morbidity and mortality of children. Although data from different settings are necessary to tackle such types of problems, the pieces of evidence are limited in the case of clinical adherence level. Therefore, this study was intended to assess clinical non-adherence and its associated factors among HIV-infected pediatrics on highly active antiretroviral therapy. METHODS: A multi-center cross-sectional study was conducted from July 1 to August 30, 2021, among HIV-infected children receiving ART in the South Gondar Zone. Data were collected through face-to-face interviews, and reviewing patients’ documents using a structured checklist. Data were entered into Epi-data version 4.6 and exported to the Statistical Package for Social Science version 23 for analysis. Binary logistic regression was used to assess the association between the factors and the outcome variable. The significance of variables was declared when a p-value was less than 0.05. RESULTS: From 422 participants, 383 have involved in the study making the response rate of 90.7%. Almost half of the study participants 190 (49.6%) were girls. Two hundred ninety-one (76%) of caretakers were biological mothers, and 203 (53%) did not have adherence supporters. About 179 (46.7%) of caretakers did not disclose the status of the child about the illness. The overall prevalence of non-adherence among children on ART was 31.9% (95% CI: 27.2–36.6). Rural residency, diagnostic status non-disclosure, no adherence supporter, having no biological caretaker and co-morbid illness were significantly associated with clinical non-adherence of HIV positive children. CONCLUSION: Clinical non-adherence among children among HIV-positive children attending care in south Gondar zone health facilities is unacceptably high. Attention shall be given to HIV-positive pediatrics who reside in rural areas, whose status was not disclosed, had no adherence supporter, had a non-biological caretaker, and had comorbidity to have good clinical adherence on ART service.
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spelling pubmed-88095182022-02-03 Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021 Tiruneh, Chalie Marew Emiru, Tigabu Desie Tibebu, Nigusie Selomon Abate, Moges Wubneh Nigat, Adane Birhanu Bantie, Berihun Belete, Amsalu Walle, Belete Gelaw Legas, Getasew Getu, Bisrat Dessie HIV AIDS (Auckl) Original Research BACKGROUND: Poor clinical adherence is the main factor that hinders ART adherence level in children and its ultimate effect on viral load suppression and decreasing morbidity and mortality of children. Although data from different settings are necessary to tackle such types of problems, the pieces of evidence are limited in the case of clinical adherence level. Therefore, this study was intended to assess clinical non-adherence and its associated factors among HIV-infected pediatrics on highly active antiretroviral therapy. METHODS: A multi-center cross-sectional study was conducted from July 1 to August 30, 2021, among HIV-infected children receiving ART in the South Gondar Zone. Data were collected through face-to-face interviews, and reviewing patients’ documents using a structured checklist. Data were entered into Epi-data version 4.6 and exported to the Statistical Package for Social Science version 23 for analysis. Binary logistic regression was used to assess the association between the factors and the outcome variable. The significance of variables was declared when a p-value was less than 0.05. RESULTS: From 422 participants, 383 have involved in the study making the response rate of 90.7%. Almost half of the study participants 190 (49.6%) were girls. Two hundred ninety-one (76%) of caretakers were biological mothers, and 203 (53%) did not have adherence supporters. About 179 (46.7%) of caretakers did not disclose the status of the child about the illness. The overall prevalence of non-adherence among children on ART was 31.9% (95% CI: 27.2–36.6). Rural residency, diagnostic status non-disclosure, no adherence supporter, having no biological caretaker and co-morbid illness were significantly associated with clinical non-adherence of HIV positive children. CONCLUSION: Clinical non-adherence among children among HIV-positive children attending care in south Gondar zone health facilities is unacceptably high. Attention shall be given to HIV-positive pediatrics who reside in rural areas, whose status was not disclosed, had no adherence supporter, had a non-biological caretaker, and had comorbidity to have good clinical adherence on ART service. Dove 2022-01-29 /pmc/articles/PMC8809518/ /pubmed/35125892 http://dx.doi.org/10.2147/HIV.S352386 Text en © 2022 Tiruneh et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tiruneh, Chalie Marew
Emiru, Tigabu Desie
Tibebu, Nigusie Selomon
Abate, Moges Wubneh
Nigat, Adane Birhanu
Bantie, Berihun
Belete, Amsalu
Walle, Belete Gelaw
Legas, Getasew
Getu, Bisrat Dessie
Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021
title Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021
title_full Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021
title_fullStr Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021
title_full_unstemmed Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021
title_short Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021
title_sort clinical non-adherence and its associated factors among hiv-positive pediatric patients attending hiv care in south gondar zone public health facilities, northwest ethiopia, 2021
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809518/
https://www.ncbi.nlm.nih.gov/pubmed/35125892
http://dx.doi.org/10.2147/HIV.S352386
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