Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells

eEF-2K has important roles in stress responses and cellular metabolism. We report here a previously unappreciated but critical role of eEF-2K in regulating the fate and cytocidal activity of CD8(+) T cells. CD8(+) T cells from eEF-2K KO mice were more proliferative but had lower survival than their...

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Detalles Bibliográficos
Autores principales: Das, Jugal Kishore, Ren, Yijie, Kumar, Anil, Peng, Hao-Yun, Wang, Liqing, Xiong, Xiaofang, Alaniz, Robert C., de Figueiredo, Paul, Ren, Xingcong, Liu, Xiaoqi, Ryazonov, Alexey G., Yang, Jin-Ming, Song, Jianxun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809536/
https://www.ncbi.nlm.nih.gov/pubmed/35108044
http://dx.doi.org/10.1126/sciadv.abl9783

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