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Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences

Assessing and selecting the most viable embryos for transfer is an essential part of in vitro fertilization (IVF). In recent years, several approaches have been made to improve and automate the procedure using artificial intelligence (AI) and deep learning. Based on images of embryos with known impl...

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Autores principales: Berntsen, Jørgen, Rimestad, Jens, Lassen, Jacob Theilgaard, Tran, Dang, Kragh, Mikkel Fly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809568/
https://www.ncbi.nlm.nih.gov/pubmed/35108306
http://dx.doi.org/10.1371/journal.pone.0262661
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author Berntsen, Jørgen
Rimestad, Jens
Lassen, Jacob Theilgaard
Tran, Dang
Kragh, Mikkel Fly
author_facet Berntsen, Jørgen
Rimestad, Jens
Lassen, Jacob Theilgaard
Tran, Dang
Kragh, Mikkel Fly
author_sort Berntsen, Jørgen
collection PubMed
description Assessing and selecting the most viable embryos for transfer is an essential part of in vitro fertilization (IVF). In recent years, several approaches have been made to improve and automate the procedure using artificial intelligence (AI) and deep learning. Based on images of embryos with known implantation data (KID), AI models have been trained to automatically score embryos related to their chance of achieving a successful implantation. However, as of now, only limited research has been conducted to evaluate how embryo selection models generalize to new clinics and how they perform in subgroup analyses across various conditions. In this paper, we investigate how a deep learning-based embryo selection model using only time-lapse image sequences performs across different patient ages and clinical conditions, and how it correlates with traditional morphokinetic parameters. The model was trained and evaluated based on a large dataset from 18 IVF centers consisting of 115,832 embryos, of which 14,644 embryos were transferred KID embryos. In an independent test set, the AI model sorted KID embryos with an area under the curve (AUC) of a receiver operating characteristic curve of 0.67 and all embryos with an AUC of 0.95. A clinic hold-out test showed that the model generalized to new clinics with an AUC range of 0.60–0.75 for KID embryos. Across different subgroups of age, insemination method, incubation time, and transfer protocol, the AUC ranged between 0.63 and 0.69. Furthermore, model predictions correlated positively with blastocyst grading and negatively with direct cleavages. The fully automated iDAScore v1.0 model was shown to perform at least as good as a state-of-the-art manual embryo selection model. Moreover, full automatization of embryo scoring implies fewer manual evaluations and eliminates biases due to inter- and intraobserver variation.
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spelling pubmed-88095682022-02-03 Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences Berntsen, Jørgen Rimestad, Jens Lassen, Jacob Theilgaard Tran, Dang Kragh, Mikkel Fly PLoS One Research Article Assessing and selecting the most viable embryos for transfer is an essential part of in vitro fertilization (IVF). In recent years, several approaches have been made to improve and automate the procedure using artificial intelligence (AI) and deep learning. Based on images of embryos with known implantation data (KID), AI models have been trained to automatically score embryos related to their chance of achieving a successful implantation. However, as of now, only limited research has been conducted to evaluate how embryo selection models generalize to new clinics and how they perform in subgroup analyses across various conditions. In this paper, we investigate how a deep learning-based embryo selection model using only time-lapse image sequences performs across different patient ages and clinical conditions, and how it correlates with traditional morphokinetic parameters. The model was trained and evaluated based on a large dataset from 18 IVF centers consisting of 115,832 embryos, of which 14,644 embryos were transferred KID embryos. In an independent test set, the AI model sorted KID embryos with an area under the curve (AUC) of a receiver operating characteristic curve of 0.67 and all embryos with an AUC of 0.95. A clinic hold-out test showed that the model generalized to new clinics with an AUC range of 0.60–0.75 for KID embryos. Across different subgroups of age, insemination method, incubation time, and transfer protocol, the AUC ranged between 0.63 and 0.69. Furthermore, model predictions correlated positively with blastocyst grading and negatively with direct cleavages. The fully automated iDAScore v1.0 model was shown to perform at least as good as a state-of-the-art manual embryo selection model. Moreover, full automatization of embryo scoring implies fewer manual evaluations and eliminates biases due to inter- and intraobserver variation. Public Library of Science 2022-02-02 /pmc/articles/PMC8809568/ /pubmed/35108306 http://dx.doi.org/10.1371/journal.pone.0262661 Text en © 2022 Berntsen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Berntsen, Jørgen
Rimestad, Jens
Lassen, Jacob Theilgaard
Tran, Dang
Kragh, Mikkel Fly
Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
title Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
title_full Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
title_fullStr Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
title_full_unstemmed Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
title_short Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
title_sort robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809568/
https://www.ncbi.nlm.nih.gov/pubmed/35108306
http://dx.doi.org/10.1371/journal.pone.0262661
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