Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor–induced dipeptidase-1 expression and glutathione depletion

Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, an...

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Detalles Bibliográficos
Autores principales: von Mässenhausen, Anne, Zamora Gonzalez, Nadia, Maremonti, Francesca, Belavgeni, Alexia, Tonnus, Wulf, Meyer, Claudia, Beer, Kristina, Hannani, Monica T., Lau, Arthur, Peitzsch, Mirko, Hoppenz, Paul, Locke, Sophie, Chavakis, Triantafyllos, Kramann, Rafael, Muruve, Daniel A., Hugo, Christian, Bornstein, Stefan R., Linkermann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809683/
https://www.ncbi.nlm.nih.gov/pubmed/35108055
http://dx.doi.org/10.1126/sciadv.abl8920

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