Radiation Therapy Enhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial

Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable (MSS) colorectal (CRC) and pancreatic (PDAC) cancer remains challenging. We conducted a single-arm, non-randomized, Phase 2 trial (NCT03104439) combining radiation, ipilimumab and nivolumab in patients with metas...

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Detalles Bibliográficos
Autores principales: Parikh, Aparna R., Szabolcs, Annamaria, Allen, Jill N., Clark, Jeffrey W., Wo, Jennifer Y., Raabe, Michael, Thel, Hannah, Hoyos, David, Mehta, Arnav, Arshad, Sanya, Lieb, David J., Drapek, Lorraine C., Blaszkowsky, Lawrence S., Giantonio, Bruce J., Weekes, Colin D., Zhu, Andrew X., Goyal, Lipika, Nipp, Ryan D., Dubois, Jon S., van Seventer, Emily E., Foreman, Bronwen E., Matlack, Lauren E., Ly, Leilana, Meurer, Jessica A., Hacohen, Nir, Ryan, David P., Yeap, Beow Y., Corcoran, Ryan B., Greenbaum, Benjamin D., Ting, David T., Hong, Theodore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809884/
https://www.ncbi.nlm.nih.gov/pubmed/35122060
http://dx.doi.org/10.1038/s43018-021-00269-7

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