Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs

Regulation of gene expression requires the combinatorial binding of sequence-specific transcription factors (TFs) at promoters and enhancers. Prior studies showed that alterations in the spacing between TF binding sites can influence promoter and enhancer activity. However, the relative importance o...

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Detalles Bibliográficos
Autores principales: Shen, Zeyang, Li, Rick Z, Prohaska, Thomas A, Hoeksema, Marten A, Spann, Nathan J, Tao, Jenhan, Fonseca, Gregory J, Le, Thomas, Stolze, Lindsey K, Sakai, Mashito, Romanoski, Casey E, Glass, Christopher K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809895/
https://www.ncbi.nlm.nih.gov/pubmed/35049498
http://dx.doi.org/10.7554/eLife.70878

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