Cargando…
Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis
Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810001/ https://www.ncbi.nlm.nih.gov/pubmed/34738503 http://dx.doi.org/10.1080/21655979.2021.1997699 |
_version_ | 1784644148228259840 |
---|---|
author | Zou, Chen Li, Xia Lv, Xiaozhi Wu, Siyuan Song, Jing Tang, Zhe Luo, Hailing Wei, Haigang Ai, Yilong |
author_facet | Zou, Chen Li, Xia Lv, Xiaozhi Wu, Siyuan Song, Jing Tang, Zhe Luo, Hailing Wei, Haigang Ai, Yilong |
author_sort | Zou, Chen |
collection | PubMed |
description | Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising direction for the development of OSCC therapeutic targets. In this study, we aimed to investigate the role of circMTO1 in OSCC progression. First, we validated the characterization and expression of circMTO1 in OSCC. It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. Subsequently, we conducted biological experiments. It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. Furthermore, we conducted a series of experiments to elucidate the underlying mechanisms. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Moreover, we found that circMTO1 expression in OSCC was transcriptionally regulated by Zinc Finger Protein 460 (ZNF460). Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development. |
format | Online Article Text |
id | pubmed-8810001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-88100012022-02-03 Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis Zou, Chen Li, Xia Lv, Xiaozhi Wu, Siyuan Song, Jing Tang, Zhe Luo, Hailing Wei, Haigang Ai, Yilong Bioengineered Research Paper Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising direction for the development of OSCC therapeutic targets. In this study, we aimed to investigate the role of circMTO1 in OSCC progression. First, we validated the characterization and expression of circMTO1 in OSCC. It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. Subsequently, we conducted biological experiments. It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. Furthermore, we conducted a series of experiments to elucidate the underlying mechanisms. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Moreover, we found that circMTO1 expression in OSCC was transcriptionally regulated by Zinc Finger Protein 460 (ZNF460). Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development. Taylor & Francis 2021-12-07 /pmc/articles/PMC8810001/ /pubmed/34738503 http://dx.doi.org/10.1080/21655979.2021.1997699 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Zou, Chen Li, Xia Lv, Xiaozhi Wu, Siyuan Song, Jing Tang, Zhe Luo, Hailing Wei, Haigang Ai, Yilong Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis |
title | Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis |
title_full | Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis |
title_fullStr | Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis |
title_full_unstemmed | Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis |
title_short | Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis |
title_sort | circular rna mitochondrial translation optimization 1 homologue (circmto1) induced by zinc finger protein 460 (znf460) promotes oral squamous cell carcinoma progression through the microrna mir-320a / alpha thalassemia/mental retardation, x-linked (atrx) axis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810001/ https://www.ncbi.nlm.nih.gov/pubmed/34738503 http://dx.doi.org/10.1080/21655979.2021.1997699 |
work_keys_str_mv | AT zouchen circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT lixia circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT lvxiaozhi circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT wusiyuan circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT songjing circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT tangzhe circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT luohailing circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT weihaigang circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis AT aiyilong circularrnamitochondrialtranslationoptimization1homologuecircmto1inducedbyzincfingerprotein460znf460promotesoralsquamouscellcarcinomaprogressionthroughthemicrornamir320aalphathalassemiamentalretardationxlinkedatrxaxis |