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Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation

Dexmedetomidine (DEX) has been reported to attenuate cecal ligation perforation (CLP)-stimulated acute lung injury (ALI) by downregulating HMGB1 and RAGE. This study aimed to further investigate the specific mechanisms of RAGE and its potential-related mechanisms of DEX on ALI models in vitro and in...

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Detalles Bibliográficos
Autores principales:	Sun, Huaqin, Hu, Hongyi, Xu, Xiaoping, Fang, Mingsun, Tao, Tao, Liang, Zhehao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810048/ https://www.ncbi.nlm.nih.gov/pubmed/34747306 http://dx.doi.org/10.1080/21655979.2021.2000723

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