The eptinezumab:CGRP complex structure – the role of conformational changes in binding stabilization

To further elucidate the mechanism of action and binding properties of eptinezumab to calcitonin gene-related peptide (CGRP), X-ray crystallography, computational alanine scanning, and molecular dynamics were used. X-ray diffraction data were collected to determine the three-dimensional structures o...

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Detalles Bibliográficos
Autores principales: David, Laurent, Scalley-Kim, Michelle, Olland, Andrea, White, Andre, Misura, Kira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810155/
https://www.ncbi.nlm.nih.gov/pubmed/34895054
http://dx.doi.org/10.1080/21655979.2021.2006977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810155/
https://www.ncbi.nlm.nih.gov/pubmed/34895054
http://dx.doi.org/10.1080/21655979.2021.2006977

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