Cargando…
The eptinezumab:CGRP complex structure – the role of conformational changes in binding stabilization
To further elucidate the mechanism of action and binding properties of eptinezumab to calcitonin gene-related peptide (CGRP), X-ray crystallography, computational alanine scanning, and molecular dynamics were used. X-ray diffraction data were collected to determine the three-dimensional structures o...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810155/ https://www.ncbi.nlm.nih.gov/pubmed/34895054 http://dx.doi.org/10.1080/21655979.2021.2006977 |