COVID-19 mRNA Vaccine-induced Pneumonitis

A 65-year-old man experienced cough and shortness of breath 3 days after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray revealed bilateral infiltrates, and the desaturation deteriorated rapidly. The symptoms and radiographic abnormalities rap...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuzaki, Shinichi, Kamiya, Hiroyuki, Inoshima, Ichiro, Hirasawa, Yasutaka, Tago, Osamu, Arai, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810239/
https://www.ncbi.nlm.nih.gov/pubmed/34707048
http://dx.doi.org/10.2169/internalmedicine.8310-21
_version_ 1784644209381212160
author Matsuzaki, Shinichi
Kamiya, Hiroyuki
Inoshima, Ichiro
Hirasawa, Yasutaka
Tago, Osamu
Arai, Masashi
author_facet Matsuzaki, Shinichi
Kamiya, Hiroyuki
Inoshima, Ichiro
Hirasawa, Yasutaka
Tago, Osamu
Arai, Masashi
author_sort Matsuzaki, Shinichi
collection PubMed
description A 65-year-old man experienced cough and shortness of breath 3 days after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray revealed bilateral infiltrates, and the desaturation deteriorated rapidly. The symptoms and radiographic abnormalities rapidly improved after the initiation of corticosteroid therapy. Intradermal testing of the Pfizer-BioNTech COVID-19 vaccine showed a delayed positive reaction. Based on these findings, the patient was diagnosed with COVID-19 vaccine-induced pneumonitis. The timing of the onset of pneumonitis after vaccination and the results of intradermal testing suggest that Type IV hypersensitivity against COVID-19 vaccine may have been responsible for this clinical condition.
format Online
Article
Text
id pubmed-8810239
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-88102392022-02-15 COVID-19 mRNA Vaccine-induced Pneumonitis Matsuzaki, Shinichi Kamiya, Hiroyuki Inoshima, Ichiro Hirasawa, Yasutaka Tago, Osamu Arai, Masashi Intern Med Case Report A 65-year-old man experienced cough and shortness of breath 3 days after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray revealed bilateral infiltrates, and the desaturation deteriorated rapidly. The symptoms and radiographic abnormalities rapidly improved after the initiation of corticosteroid therapy. Intradermal testing of the Pfizer-BioNTech COVID-19 vaccine showed a delayed positive reaction. Based on these findings, the patient was diagnosed with COVID-19 vaccine-induced pneumonitis. The timing of the onset of pneumonitis after vaccination and the results of intradermal testing suggest that Type IV hypersensitivity against COVID-19 vaccine may have been responsible for this clinical condition. The Japanese Society of Internal Medicine 2021-10-26 2022-01-01 /pmc/articles/PMC8810239/ /pubmed/34707048 http://dx.doi.org/10.2169/internalmedicine.8310-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsuzaki, Shinichi
Kamiya, Hiroyuki
Inoshima, Ichiro
Hirasawa, Yasutaka
Tago, Osamu
Arai, Masashi
COVID-19 mRNA Vaccine-induced Pneumonitis
title COVID-19 mRNA Vaccine-induced Pneumonitis
title_full COVID-19 mRNA Vaccine-induced Pneumonitis
title_fullStr COVID-19 mRNA Vaccine-induced Pneumonitis
title_full_unstemmed COVID-19 mRNA Vaccine-induced Pneumonitis
title_short COVID-19 mRNA Vaccine-induced Pneumonitis
title_sort covid-19 mrna vaccine-induced pneumonitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810239/
https://www.ncbi.nlm.nih.gov/pubmed/34707048
http://dx.doi.org/10.2169/internalmedicine.8310-21
work_keys_str_mv AT matsuzakishinichi covid19mrnavaccineinducedpneumonitis
AT kamiyahiroyuki covid19mrnavaccineinducedpneumonitis
AT inoshimaichiro covid19mrnavaccineinducedpneumonitis
AT hirasawayasutaka covid19mrnavaccineinducedpneumonitis
AT tagoosamu covid19mrnavaccineinducedpneumonitis
AT araimasashi covid19mrnavaccineinducedpneumonitis

Ejemplares similares