Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is widely used as a flame retardant and is known to exhibit anti-androgenic effects in vitro and in vivo. To assess the reproductive toxicity potency of TDCIPP, we investigated the effects of 7 days of TDCIPP oral administration on epididymal sperm moti...

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Autores principales: KOBAYASHI, Shohei, KAWANO, Natsuko, MIYADO, Kenji, OHTA, Ryo, AKIMOTO, Takahiro, HATAKEYAMA, Taichi, KAWAGUCHI, Maiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810334/
https://www.ncbi.nlm.nih.gov/pubmed/34897185
http://dx.doi.org/10.1292/jvms.21-0046
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author KOBAYASHI, Shohei
KAWANO, Natsuko
MIYADO, Kenji
OHTA, Ryo
AKIMOTO, Takahiro
HATAKEYAMA, Taichi
KAWAGUCHI, Maiko
author_facet KOBAYASHI, Shohei
KAWANO, Natsuko
MIYADO, Kenji
OHTA, Ryo
AKIMOTO, Takahiro
HATAKEYAMA, Taichi
KAWAGUCHI, Maiko
author_sort KOBAYASHI, Shohei
collection PubMed
description Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is widely used as a flame retardant and is known to exhibit anti-androgenic effects in vitro and in vivo. To assess the reproductive toxicity potency of TDCIPP, we investigated the effects of 7 days of TDCIPP oral administration on epididymal sperm motion and concentration in adult male Wistar–Imamichi rats. Thirty-five days after the final administration, sperm parameters were evaluated by computer-assisted sperm analysis. Results showed that sperm swimming progression and vigor and sperm concentration in TDCIPP-treated rats were unexpectedly higher than those in control rats. TDCIPP did not significantly affect the percentage of motile sperms or sperm swimming pattern. These results contribute to the understanding of the biological effects of TDCIPP.
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spelling pubmed-88103342022-02-25 Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats KOBAYASHI, Shohei KAWANO, Natsuko MIYADO, Kenji OHTA, Ryo AKIMOTO, Takahiro HATAKEYAMA, Taichi KAWAGUCHI, Maiko J Vet Med Sci Toxicology Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is widely used as a flame retardant and is known to exhibit anti-androgenic effects in vitro and in vivo. To assess the reproductive toxicity potency of TDCIPP, we investigated the effects of 7 days of TDCIPP oral administration on epididymal sperm motion and concentration in adult male Wistar–Imamichi rats. Thirty-five days after the final administration, sperm parameters were evaluated by computer-assisted sperm analysis. Results showed that sperm swimming progression and vigor and sperm concentration in TDCIPP-treated rats were unexpectedly higher than those in control rats. TDCIPP did not significantly affect the percentage of motile sperms or sperm swimming pattern. These results contribute to the understanding of the biological effects of TDCIPP. The Japanese Society of Veterinary Science 2021-12-10 2022-01 /pmc/articles/PMC8810334/ /pubmed/34897185 http://dx.doi.org/10.1292/jvms.21-0046 Text en ©2022 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Toxicology
KOBAYASHI, Shohei
KAWANO, Natsuko
MIYADO, Kenji
OHTA, Ryo
AKIMOTO, Takahiro
HATAKEYAMA, Taichi
KAWAGUCHI, Maiko
Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
title Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
title_full Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
title_fullStr Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
title_full_unstemmed Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
title_short Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
title_sort effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats
topic Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810334/
https://www.ncbi.nlm.nih.gov/pubmed/34897185
http://dx.doi.org/10.1292/jvms.21-0046
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