Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. Here, we show that the Rho effector protein kinase N2 (PKN2) is critical for PSC myofibroblast...

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Detalles Bibliográficos
Autores principales: Murray, Elizabeth R., Menezes, Shinelle, Henry, Jack C., Williams, Josie L., Alba-Castellón, Lorena, Baskaran, Priththivika, Quétier, Ivan, Desai, Ami, Marshall, Jacqueline J.T., Rosewell, Ian, Tatari, Marianthi, Rajeeve, Vinothini, Khan, Faraz, Wang, Jun, Kotantaki, Panoraia, Tyler, Eleanor J., Singh, Namrata, Reader, Claire S., Carter, Edward P., Hodivala-Dilke, Kairbaan, Grose, Richard P., Kocher, Hemant M., Gavara, Nuria, Pearce, Oliver, Cutillas, Pedro, Marshall, John F., Cameron, Angus J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810397/
https://www.ncbi.nlm.nih.gov/pubmed/35081338
http://dx.doi.org/10.1016/j.celrep.2021.110227

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