PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways

Infiltration of arterial intima by foamy macrophages is a hallmark of early atherosclerotic lesions. Here, we investigated the potential role of Ser/Thr phosphatase PHLPP1 in foam cell development. PHLPP1 levels were elevated in OxLDL-exposed macrophages and high-fat diet (HFD)-fed zebrafish larvae....

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Detalles Bibliográficos
Autores principales: Balamurugan, Keerthana, Medishetti, Raghavender, Kotha, Jyothi, Behera, Parameshwar, Chandra, Kanika, Mavuduru, Vijay Aditya, Joshi, Manjunath B., Samineni, Ramesh, Katika, Madhumohan R., Ball, Writoban Basu, Thondamal, Manjunatha, Challa, Anil, Chatti, Kiranam, Parsa, Kishore V.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810408/
https://www.ncbi.nlm.nih.gov/pubmed/35141506
http://dx.doi.org/10.1016/j.isci.2022.103766

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