A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques

BACKGROUND: Human monoclonal antibody (mAb) treatments are promising for COVID-19 prevention or therapy. The pre-exposure prophylactic efficacy of neutralizing antibodies that are engineered with mutations to extend their persistence in human serum and the neutralizing antibody titer in serum requir...

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Detalles Bibliográficos
Autores principales: Cobb, Ronald R., Nkolola, Joseph, Gilchuk, Pavlo, Chandrashekar, Abishek, Yu, Jingyou, House, Robert V., Earnhart, Christopher G., Dorsey, Nicole M., Hopkins, Svetlana A., Snow, Doris M., Chen, Rita E., VanBlargan, Laura A., Hechenblaickner, Manuel, Hoppe, Brian, Collins, Laura, Tomic, Milan T., Nonet, Genevieve H., Hackett, Kyal, Slaughter, James C., Lewis, Mark G., Andersen, Hanne, Cook, Anthony, Diamond, Michael S., Carnahan, Robert H., Barouch, Dan H., Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Clinical and Translational Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810411/
https://www.ncbi.nlm.nih.gov/pubmed/35132398
http://dx.doi.org/10.1016/j.medj.2022.01.004

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