The Role of Gut Microbiota in Gastrointestinal Tract Cancers

Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori...

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Autores principales: Grochowska, Marta, Perlejewski, Karol, Laskus, Tomasz, Radkowski, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810472/
https://www.ncbi.nlm.nih.gov/pubmed/35112169
http://dx.doi.org/10.1007/s00005-021-00641-6
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author Grochowska, Marta
Perlejewski, Karol
Laskus, Tomasz
Radkowski, Marek
author_facet Grochowska, Marta
Perlejewski, Karol
Laskus, Tomasz
Radkowski, Marek
author_sort Grochowska, Marta
collection PubMed
description Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species: Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis as likely causative factors. This review summarizes the role of bacteria in GI tract oncogenesis.
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spelling pubmed-88104722022-02-22 The Role of Gut Microbiota in Gastrointestinal Tract Cancers Grochowska, Marta Perlejewski, Karol Laskus, Tomasz Radkowski, Marek Arch Immunol Ther Exp (Warsz) Review Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species: Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis as likely causative factors. This review summarizes the role of bacteria in GI tract oncogenesis. Springer International Publishing 2022-02-03 2022 /pmc/articles/PMC8810472/ /pubmed/35112169 http://dx.doi.org/10.1007/s00005-021-00641-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Grochowska, Marta
Perlejewski, Karol
Laskus, Tomasz
Radkowski, Marek
The Role of Gut Microbiota in Gastrointestinal Tract Cancers
title The Role of Gut Microbiota in Gastrointestinal Tract Cancers
title_full The Role of Gut Microbiota in Gastrointestinal Tract Cancers
title_fullStr The Role of Gut Microbiota in Gastrointestinal Tract Cancers
title_full_unstemmed The Role of Gut Microbiota in Gastrointestinal Tract Cancers
title_short The Role of Gut Microbiota in Gastrointestinal Tract Cancers
title_sort role of gut microbiota in gastrointestinal tract cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810472/
https://www.ncbi.nlm.nih.gov/pubmed/35112169
http://dx.doi.org/10.1007/s00005-021-00641-6
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