New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism

Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (1–6), and one new nor-diterpenoid (7). Their structures were established by comprehensive spectroscopic and spectrometri...

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Autores principales: Mirzania, Foroogh, Moridi Farimani, Mahdi, Sarrafi, Yaghoub, Nejad Ebrahimi, Samad, Troppmair, Jakob, Kwiatkowski, Marcel, Stuppner, Hermann, Alilou, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810545/
https://www.ncbi.nlm.nih.gov/pubmed/35127644
http://dx.doi.org/10.3389/fchem.2021.783292
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author Mirzania, Foroogh
Moridi Farimani, Mahdi
Sarrafi, Yaghoub
Nejad Ebrahimi, Samad
Troppmair, Jakob
Kwiatkowski, Marcel
Stuppner, Hermann
Alilou, Mostafa
author_facet Mirzania, Foroogh
Moridi Farimani, Mahdi
Sarrafi, Yaghoub
Nejad Ebrahimi, Samad
Troppmair, Jakob
Kwiatkowski, Marcel
Stuppner, Hermann
Alilou, Mostafa
author_sort Mirzania, Foroogh
collection PubMed
description Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (1–6), and one new nor-diterpenoid (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS) and DP4+ NMR chemical shift probability calculation technique. Moreover, the absolute configuration of compounds was determined by using electronic circular dichroism spectroscopy. Evaluation of antiproliferative properties of compounds isolated against four human melanoma cancer cells displayed no cytotoxic activity at the concentration range used.
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spelling pubmed-88105452022-02-04 New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism Mirzania, Foroogh Moridi Farimani, Mahdi Sarrafi, Yaghoub Nejad Ebrahimi, Samad Troppmair, Jakob Kwiatkowski, Marcel Stuppner, Hermann Alilou, Mostafa Front Chem Chemistry Phytochemical investigation on the acetone extract of Salvia mirzayanii Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (1–6), and one new nor-diterpenoid (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS) and DP4+ NMR chemical shift probability calculation technique. Moreover, the absolute configuration of compounds was determined by using electronic circular dichroism spectroscopy. Evaluation of antiproliferative properties of compounds isolated against four human melanoma cancer cells displayed no cytotoxic activity at the concentration range used. Frontiers Media S.A. 2022-01-20 /pmc/articles/PMC8810545/ /pubmed/35127644 http://dx.doi.org/10.3389/fchem.2021.783292 Text en Copyright © 2022 Mirzania, Moridi Farimani, Sarrafi, Nejad Ebrahimi, Troppmair, Kwiatkowski, Stuppner and Alilou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Mirzania, Foroogh
Moridi Farimani, Mahdi
Sarrafi, Yaghoub
Nejad Ebrahimi, Samad
Troppmair, Jakob
Kwiatkowski, Marcel
Stuppner, Hermann
Alilou, Mostafa
New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
title New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
title_full New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
title_fullStr New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
title_full_unstemmed New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
title_short New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism
title_sort new sesterterpenoids from salvia mirzayanii rech.f. and esfand. stereochemical characterization by computational electronic circular dichroism
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810545/
https://www.ncbi.nlm.nih.gov/pubmed/35127644
http://dx.doi.org/10.3389/fchem.2021.783292
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