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The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic
INTRODUCTION/OBJECTIVES: COVID-19 is associated with a prothrombotic state and elevated risk of thromboembolism. This study assesses the risk of thromboembolic events and their impact on hospitalization of COVID-19 inpatients. [Image: see text] [Image: see text] [Image: see text] METHODS: Retrospect...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810564/ http://dx.doi.org/10.1016/j.avsg.2021.12.068 |
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author | Nam, Janice D'Andrea, Melissa O'Hara, Alexander Staszewski, Lindsey Pozin, Jacob Wozniak, Amy Korepta, Lindsey Aulivola, Bernadettee |
author_facet | Nam, Janice D'Andrea, Melissa O'Hara, Alexander Staszewski, Lindsey Pozin, Jacob Wozniak, Amy Korepta, Lindsey Aulivola, Bernadettee |
author_sort | Nam, Janice |
collection | PubMed |
description | INTRODUCTION/OBJECTIVES: COVID-19 is associated with a prothrombotic state and elevated risk of thromboembolism. This study assesses the risk of thromboembolic events and their impact on hospitalization of COVID-19 inpatients. [Image: see text] [Image: see text] [Image: see text] METHODS: Retrospective review of all COVID-19 inpatients (≥18 years old) at a single academic institution from March 15, 2020 - July 1, 2020 was performed. Patient data included demographics, comorbidities, hospital admission type, thromboembolic events, laboratory values, use of anticoagulants/antiplatelets, hospital length of stay, and mortality. RESULTS: Within 826 COVID-19 inpatients (56% male, 44% female) identified, 87 patients (10.5%) had 98 thromboembolic events. (Table 1). Hypertension, CAD, and CLTI were associated with increased incidence of thromboembolism (p <0.05). Non-white patients had higher incidence of thromboembolism [OR (CI): 2.43 (1.279, 4.616), p=0.007]. As D-dimer increased by 500 unit increments, the odds of developing a thromboembolic event increased by 5.2% [OR (CI): 1.052 (1.027, 1.077), p<0.001]. (Table 2). Patients with thromboembolism had higher antiplatelet/anticoagulants usage (p <.05), longer hospital LOS (Mean: 17.8 vs 9.0, p <0.001), higher ICU admission (63% vs 33%, p<0.001), and higher in-hospital mortality (28% vs 16%, p =0.006). (Table 3). CONCLUSIONS: Increased D-dimer, CAD, and CLTI are associated with elevated risk of thromboembolic events in hospitalized COVID-19 patients while smoking status had no association. Non-white patients had increased risk of thromboembolism. Patients with thromboembolism had higher antiplatelet/anticoagulant usage, longer LOS, higher ICU admissions, and increased mortality. [Image: see text] [Image: see text] |
format | Online Article Text |
id | pubmed-8810564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88105642022-02-03 The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic Nam, Janice D'Andrea, Melissa O'Hara, Alexander Staszewski, Lindsey Pozin, Jacob Wozniak, Amy Korepta, Lindsey Aulivola, Bernadettee Ann Vasc Surg Article INTRODUCTION/OBJECTIVES: COVID-19 is associated with a prothrombotic state and elevated risk of thromboembolism. This study assesses the risk of thromboembolic events and their impact on hospitalization of COVID-19 inpatients. [Image: see text] [Image: see text] [Image: see text] METHODS: Retrospective review of all COVID-19 inpatients (≥18 years old) at a single academic institution from March 15, 2020 - July 1, 2020 was performed. Patient data included demographics, comorbidities, hospital admission type, thromboembolic events, laboratory values, use of anticoagulants/antiplatelets, hospital length of stay, and mortality. RESULTS: Within 826 COVID-19 inpatients (56% male, 44% female) identified, 87 patients (10.5%) had 98 thromboembolic events. (Table 1). Hypertension, CAD, and CLTI were associated with increased incidence of thromboembolism (p <0.05). Non-white patients had higher incidence of thromboembolism [OR (CI): 2.43 (1.279, 4.616), p=0.007]. As D-dimer increased by 500 unit increments, the odds of developing a thromboembolic event increased by 5.2% [OR (CI): 1.052 (1.027, 1.077), p<0.001]. (Table 2). Patients with thromboembolism had higher antiplatelet/anticoagulants usage (p <.05), longer hospital LOS (Mean: 17.8 vs 9.0, p <0.001), higher ICU admission (63% vs 33%, p<0.001), and higher in-hospital mortality (28% vs 16%, p =0.006). (Table 3). CONCLUSIONS: Increased D-dimer, CAD, and CLTI are associated with elevated risk of thromboembolic events in hospitalized COVID-19 patients while smoking status had no association. Non-white patients had increased risk of thromboembolism. Patients with thromboembolism had higher antiplatelet/anticoagulant usage, longer LOS, higher ICU admissions, and increased mortality. [Image: see text] [Image: see text] Published by Elsevier B.V. 2022-02 2022-02-03 /pmc/articles/PMC8810564/ http://dx.doi.org/10.1016/j.avsg.2021.12.068 Text en Copyright © 2022 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Nam, Janice D'Andrea, Melissa O'Hara, Alexander Staszewski, Lindsey Pozin, Jacob Wozniak, Amy Korepta, Lindsey Aulivola, Bernadettee The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic |
title | The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic |
title_full | The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic |
title_fullStr | The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic |
title_full_unstemmed | The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic |
title_short | The Risk Of Thromboembolic Events In COVID-19 Patients During The Height Of The SARS-CoV-2 Pandemic |
title_sort | risk of thromboembolic events in covid-19 patients during the height of the sars-cov-2 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810564/ http://dx.doi.org/10.1016/j.avsg.2021.12.068 |
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