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Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics
Signaling by neurotrophins such as the brain‐derived neurotrophic factor (BDNF) is known to modulate development of interneurons, but the circuit effects of this modulation remain unclear. Here, we examined the impact of deleting TrkB, a BDNF receptor, in parvalbumin‐expressing (PV) interneurons on...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810709/ https://www.ncbi.nlm.nih.gov/pubmed/34491578 http://dx.doi.org/10.1002/jcp.30571 |
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author | Lau, Chunyue Geoffrey Zhang, Huiqi Murthy, Venkatesh N. |
author_facet | Lau, Chunyue Geoffrey Zhang, Huiqi Murthy, Venkatesh N. |
author_sort | Lau, Chunyue Geoffrey |
collection | PubMed |
description | Signaling by neurotrophins such as the brain‐derived neurotrophic factor (BDNF) is known to modulate development of interneurons, but the circuit effects of this modulation remain unclear. Here, we examined the impact of deleting TrkB, a BDNF receptor, in parvalbumin‐expressing (PV) interneurons on the balance of excitation and inhibition (E‐I) in cortical circuits. In the mouse olfactory cortex, TrkB deletion impairs multiple aspects of PV neuronal function including synaptic excitation, intrinsic excitability, and the innervation pattern of principal neurons. Impaired PV cell function resulted in aberrant spiking patterns in principal neurons in response to stimulation of sensory inputs. Surprisingly, dampened PV neuronal function leads to a paradoxical decrease in overall excitability in cortical circuits. Our study demonstrates that, by modulating PV circuit plasticity and development, TrkB plays a critical role in shaping the evoked pattern of activity in a cortical network. |
format | Online Article Text |
id | pubmed-8810709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88107092022-10-14 Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics Lau, Chunyue Geoffrey Zhang, Huiqi Murthy, Venkatesh N. J Cell Physiol Research Articles Signaling by neurotrophins such as the brain‐derived neurotrophic factor (BDNF) is known to modulate development of interneurons, but the circuit effects of this modulation remain unclear. Here, we examined the impact of deleting TrkB, a BDNF receptor, in parvalbumin‐expressing (PV) interneurons on the balance of excitation and inhibition (E‐I) in cortical circuits. In the mouse olfactory cortex, TrkB deletion impairs multiple aspects of PV neuronal function including synaptic excitation, intrinsic excitability, and the innervation pattern of principal neurons. Impaired PV cell function resulted in aberrant spiking patterns in principal neurons in response to stimulation of sensory inputs. Surprisingly, dampened PV neuronal function leads to a paradoxical decrease in overall excitability in cortical circuits. Our study demonstrates that, by modulating PV circuit plasticity and development, TrkB plays a critical role in shaping the evoked pattern of activity in a cortical network. John Wiley and Sons Inc. 2021-09-07 2022-01 /pmc/articles/PMC8810709/ /pubmed/34491578 http://dx.doi.org/10.1002/jcp.30571 Text en © 2021 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Lau, Chunyue Geoffrey Zhang, Huiqi Murthy, Venkatesh N. Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics |
title | Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics |
title_full | Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics |
title_fullStr | Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics |
title_full_unstemmed | Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics |
title_short | Deletion of TrkB in parvalbumin interneurons alters cortical neural dynamics |
title_sort | deletion of trkb in parvalbumin interneurons alters cortical neural dynamics |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810709/ https://www.ncbi.nlm.nih.gov/pubmed/34491578 http://dx.doi.org/10.1002/jcp.30571 |
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