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Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden

An emerging link between circadian clock function and neurodegeneration has indicated a critical role for the molecular clock in brain health. We previously reported that deletion of the core circadian clock gene Bmal1 abrogates clock function and induces cell-autonomous astrocyte activation. Regula...

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Detalles Bibliográficos
Autores principales:	McKee, Celia A., Lee, Jiyeon, Cai, Yuqi, Saito, Takashi, Saido, Takaomi, Musiek, Erik S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810760/ https://www.ncbi.nlm.nih.gov/pubmed/35110643 http://dx.doi.org/10.1038/s41598-022-05862-z

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