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Computational discovery of binding mode of anti-TRBC1 antibody and predicted key amino acids of TRBC1

Peripheral T-cell lymphoma (PTCL) is a type of non-Hodgkin lymphoma that progresses aggressively with poor survival rate. CAR T cell targeting T-cell receptor β-chain constant domains 1 (TRBC1) of malignant T cells has been developed recently by using JOVI.1 monoclonal antibody as a template. Howeve...

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Detalles Bibliográficos
Autores principales:	Saetang, Jirakrit, Sangkhathat, Surasak, Jangphattananont, Nawaphat, Khopanlert, Wannakorn, Julamanee, Jakrawadee, Tipmanee, Varomyalin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810837/ https://www.ncbi.nlm.nih.gov/pubmed/35110642 http://dx.doi.org/10.1038/s41598-022-05742-6

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