Manipulation of RNA polymerase III by Herpes Simplex Virus-1

RNA polymerase III (Pol III) transcribes noncoding RNA, including transfer RNA (tRNA), and is commonly targeted during cancer and viral infection. We find that Herpes Simplex Virus-1 (HSV-1) stimulates tRNA expression 10-fold. Perturbation of host tRNA synthesis requires nuclear viral entry, but not...

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Detalles Bibliográficos
Autores principales: Dremel, Sarah E., Sivrich, Frances L., Tucker, Jessica M., Glaunsinger, Britt A., DeLuca, Neal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810925/
https://www.ncbi.nlm.nih.gov/pubmed/35110532
http://dx.doi.org/10.1038/s41467-022-28144-8

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