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Identification of novel leads as potent inhibitors of HDAC3 using ligand-based pharmacophore modeling and MD simulation

In the landscape of epigenetic regulation, histone deacetylase 3 (HDAC3) has emerged as a prominent therapeutic target for the design and development of candidate drugs against various types of cancers and other human disorders. Herein, we have performed ligand-based pharmacophore modeling, virtual...

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Detalles Bibliográficos
Autores principales:	Kumbhar, Navanath, Nimal, Snehal, Barale, Sagar, Kamble, Subodh, Bavi, Rohit, Sonawane, Kailas, Gacche, Rajesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810932/ https://www.ncbi.nlm.nih.gov/pubmed/35110603 http://dx.doi.org/10.1038/s41598-022-05698-7

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