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Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study
BACKGROUND: Cerebral small vessel disease (cSVD) is a late consequence of cerebral microvascular dysfunction (MVD). MVD is hard to measure in the brain due to its limited accessibility. Extracerebral MVD (eMVD) measures can give insights in the etiology of cerebral MVD, as MVD may be a systemic proc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811003/ https://www.ncbi.nlm.nih.gov/pubmed/34816376 http://dx.doi.org/10.1007/s11357-021-00493-0 |
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author | van Dinther, Maud Schram, Miranda T. Jansen, Jacobus F. A. Backes, Walter H. Houben, Alfons J. H. M. Berendschot, Tos T. J. M. Schalkwijk, Casper G. Stehouwer, Coen D. A. van Oostenbrugge, Robert J. Staals, Julie |
author_facet | van Dinther, Maud Schram, Miranda T. Jansen, Jacobus F. A. Backes, Walter H. Houben, Alfons J. H. M. Berendschot, Tos T. J. M. Schalkwijk, Casper G. Stehouwer, Coen D. A. van Oostenbrugge, Robert J. Staals, Julie |
author_sort | van Dinther, Maud |
collection | PubMed |
description | BACKGROUND: Cerebral small vessel disease (cSVD) is a late consequence of cerebral microvascular dysfunction (MVD). MVD is hard to measure in the brain due to its limited accessibility. Extracerebral MVD (eMVD) measures can give insights in the etiology of cerebral MVD, as MVD may be a systemic process. We aim to investigate whether a compound score consisting of several eMVD measures is associated with structural cSVD MRI markers. METHODS: Cross-sectional data of the population-based Maastricht Study was used (n = 1872, mean age 59 ± 8 years, 49% women). Measures of eMVD included flicker light-induced retinal arteriolar and venular dilation response (retina), albuminuria and glomerular filtration rate (kidney), heat-induced skin hyperemia (skin), and plasma biomarkers of endothelial dysfunction (sICAM-1, sVCAM-1, sE-selectin, and von Willebrand factor). These measures were standardized into z scores and summarized into a compound score. Linear and logistic regression analyses were used to investigate the associations between the compound score and white matter hyperintensity (WMH) volume, and the presence of lacunes and microbleeds, as measured by brain MRI. RESULTS: The eMVD compound score was associated with WMH volume independent of age, sex, and cardiovascular risk factors (St β 0.057 [95% CI 0.010–0.081], p value 0.01), but not with the presence of lacunes (OR 1.011 [95% CI 0.803–1.273], p value 0.92) or microbleeds (OR 1.055 [95% CI 0.896–1.242], p value 0.52). CONCLUSION: A compound score of eMVD is associated with WMH volume. Further research is needed to expand the knowledge about the role of systemic MVD in the pathophysiology of cSVD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-021-00493-0. |
format | Online Article Text |
id | pubmed-8811003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88110032022-02-10 Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study van Dinther, Maud Schram, Miranda T. Jansen, Jacobus F. A. Backes, Walter H. Houben, Alfons J. H. M. Berendschot, Tos T. J. M. Schalkwijk, Casper G. Stehouwer, Coen D. A. van Oostenbrugge, Robert J. Staals, Julie GeroScience Original Article BACKGROUND: Cerebral small vessel disease (cSVD) is a late consequence of cerebral microvascular dysfunction (MVD). MVD is hard to measure in the brain due to its limited accessibility. Extracerebral MVD (eMVD) measures can give insights in the etiology of cerebral MVD, as MVD may be a systemic process. We aim to investigate whether a compound score consisting of several eMVD measures is associated with structural cSVD MRI markers. METHODS: Cross-sectional data of the population-based Maastricht Study was used (n = 1872, mean age 59 ± 8 years, 49% women). Measures of eMVD included flicker light-induced retinal arteriolar and venular dilation response (retina), albuminuria and glomerular filtration rate (kidney), heat-induced skin hyperemia (skin), and plasma biomarkers of endothelial dysfunction (sICAM-1, sVCAM-1, sE-selectin, and von Willebrand factor). These measures were standardized into z scores and summarized into a compound score. Linear and logistic regression analyses were used to investigate the associations between the compound score and white matter hyperintensity (WMH) volume, and the presence of lacunes and microbleeds, as measured by brain MRI. RESULTS: The eMVD compound score was associated with WMH volume independent of age, sex, and cardiovascular risk factors (St β 0.057 [95% CI 0.010–0.081], p value 0.01), but not with the presence of lacunes (OR 1.011 [95% CI 0.803–1.273], p value 0.92) or microbleeds (OR 1.055 [95% CI 0.896–1.242], p value 0.52). CONCLUSION: A compound score of eMVD is associated with WMH volume. Further research is needed to expand the knowledge about the role of systemic MVD in the pathophysiology of cSVD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11357-021-00493-0. Springer International Publishing 2021-11-23 /pmc/articles/PMC8811003/ /pubmed/34816376 http://dx.doi.org/10.1007/s11357-021-00493-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article van Dinther, Maud Schram, Miranda T. Jansen, Jacobus F. A. Backes, Walter H. Houben, Alfons J. H. M. Berendschot, Tos T. J. M. Schalkwijk, Casper G. Stehouwer, Coen D. A. van Oostenbrugge, Robert J. Staals, Julie Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study |
title | Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study |
title_full | Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study |
title_fullStr | Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study |
title_full_unstemmed | Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study |
title_short | Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study |
title_sort | extracerebral microvascular dysfunction is related to brain mri markers of cerebral small vessel disease: the maastricht study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811003/ https://www.ncbi.nlm.nih.gov/pubmed/34816376 http://dx.doi.org/10.1007/s11357-021-00493-0 |
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