BMI1 nuclear location is critical for RAD51-dependent response to replication stress and drives chemoresistance in breast cancer stem cells

Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication. We demonstrated that bCSCs present a limited level of RS compared with no...

Descripción completa

Detalles Bibliográficos
Autores principales: Azzoni, Violette, Wicinski, Julien, Macario, Manon, Castagné, Martin, Finetti, Pascal, Ambrosova, Katerina, Rouault, Célia D., Sergé, Arnaud, Farina, Anne, Agavnian, Emilie, Coslet, Sergiu, Josselin, Emmanuelle, Guille, Arnaud, Adelaide, José, Zacharioudakis, Emmanouil, Castellano, Rémy, Bertucci, Francois, Birnbaum, Daniel, Rodriguez, Raphael, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811067/
https://www.ncbi.nlm.nih.gov/pubmed/35110528
http://dx.doi.org/10.1038/s41419-022-04538-w

Ejemplares similares

Ejemplares similares