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Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review
Perioperative interventions produce substantial biologic perturbations which are associated with the risk of recurrence after cancer surgery. The changes of tumor microenvironment caused by anesthetic drugs received increasing attention. Till now, it’s still unclear whether or not anesthetic drugs m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811129/ https://www.ncbi.nlm.nih.gov/pubmed/35127500 http://dx.doi.org/10.3389/fonc.2021.793093 |
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author | Fang, Panpan Zhou, Jiaqi Xia, Zhengyuan Lu, Yao Liu, Xuesheng |
author_facet | Fang, Panpan Zhou, Jiaqi Xia, Zhengyuan Lu, Yao Liu, Xuesheng |
author_sort | Fang, Panpan |
collection | PubMed |
description | Perioperative interventions produce substantial biologic perturbations which are associated with the risk of recurrence after cancer surgery. The changes of tumor microenvironment caused by anesthetic drugs received increasing attention. Till now, it’s still unclear whether or not anesthetic drugs may exert positive or negative impact on cancer outcomes after surgery. Breast cancer is the most common tumor and the leading cause of cancer deaths in women. Propofol and sevoflurane are respectively the most commonly used intravenous and inhaled anesthetics. Debates regarding which of the two most commonly used anesthetics may relatively contribute to the recurrence and metastasis vulnerability of breast cancer postoperatively remain. This review aimed to provide a comprehensive view about the effect of propofol versus sevoflurane on the prognosis of breast cancer obtained from pre-clinical studies and clinical studies. Laboratory and animal studies have demonstrated that sevoflurane may enhance the recurrence and metastasis of breast cancer, while propofol is more likely to reduce the activity of breast cancer cells by attenuating the suppression of the immune system, promoting tumor cells apoptosis, and through other direct anti-tumor effects. However, retrospective clinical studies have shown contradictory results about the effects of propofol and sevoflurane on long-term survival in breast cancer patients. Furthermore, recent prospective studies did not identify significant differences between propofol and sevoflurane in breast cancer metastasis and recurrence. Therefore, more preclinical studies and randomized controlled studies are needed to guide the choice of anesthetics for breast cancer patients. |
format | Online Article Text |
id | pubmed-8811129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88111292022-02-04 Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review Fang, Panpan Zhou, Jiaqi Xia, Zhengyuan Lu, Yao Liu, Xuesheng Front Oncol Oncology Perioperative interventions produce substantial biologic perturbations which are associated with the risk of recurrence after cancer surgery. The changes of tumor microenvironment caused by anesthetic drugs received increasing attention. Till now, it’s still unclear whether or not anesthetic drugs may exert positive or negative impact on cancer outcomes after surgery. Breast cancer is the most common tumor and the leading cause of cancer deaths in women. Propofol and sevoflurane are respectively the most commonly used intravenous and inhaled anesthetics. Debates regarding which of the two most commonly used anesthetics may relatively contribute to the recurrence and metastasis vulnerability of breast cancer postoperatively remain. This review aimed to provide a comprehensive view about the effect of propofol versus sevoflurane on the prognosis of breast cancer obtained from pre-clinical studies and clinical studies. Laboratory and animal studies have demonstrated that sevoflurane may enhance the recurrence and metastasis of breast cancer, while propofol is more likely to reduce the activity of breast cancer cells by attenuating the suppression of the immune system, promoting tumor cells apoptosis, and through other direct anti-tumor effects. However, retrospective clinical studies have shown contradictory results about the effects of propofol and sevoflurane on long-term survival in breast cancer patients. Furthermore, recent prospective studies did not identify significant differences between propofol and sevoflurane in breast cancer metastasis and recurrence. Therefore, more preclinical studies and randomized controlled studies are needed to guide the choice of anesthetics for breast cancer patients. Frontiers Media S.A. 2022-01-20 /pmc/articles/PMC8811129/ /pubmed/35127500 http://dx.doi.org/10.3389/fonc.2021.793093 Text en Copyright © 2022 Fang, Zhou, Xia, Lu and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fang, Panpan Zhou, Jiaqi Xia, Zhengyuan Lu, Yao Liu, Xuesheng Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review |
title | Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review |
title_full | Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review |
title_fullStr | Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review |
title_full_unstemmed | Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review |
title_short | Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review |
title_sort | effects of propofol versus sevoflurane on postoperative breast cancer prognosis: a narrative review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811129/ https://www.ncbi.nlm.nih.gov/pubmed/35127500 http://dx.doi.org/10.3389/fonc.2021.793093 |
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