The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program

In recent years, the ubiquitin-proteasome system (UPS) has emerged as an important regulator of stem cell function. Here we review recent findings indicating that UPS also plays critical roles in the biology of satellite cells, the muscle stem cell responsible for its maintenance and regeneration. W...

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Autor principal: Olguín, Hugo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811165/
https://www.ncbi.nlm.nih.gov/pubmed/35127730
http://dx.doi.org/10.3389/fcell.2021.821839
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author Olguín, Hugo C.
author_facet Olguín, Hugo C.
author_sort Olguín, Hugo C.
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description In recent years, the ubiquitin-proteasome system (UPS) has emerged as an important regulator of stem cell function. Here we review recent findings indicating that UPS also plays critical roles in the biology of satellite cells, the muscle stem cell responsible for its maintenance and regeneration. While we focus our attention on the control of key transcriptional regulators of satellite cell function, we briefly discuss early studies suggesting the UPS participates more broadly in the regulation of satellite cell stemness and regenerative capacity.
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spelling pubmed-88111652022-02-04 The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program Olguín, Hugo C. Front Cell Dev Biol Cell and Developmental Biology In recent years, the ubiquitin-proteasome system (UPS) has emerged as an important regulator of stem cell function. Here we review recent findings indicating that UPS also plays critical roles in the biology of satellite cells, the muscle stem cell responsible for its maintenance and regeneration. While we focus our attention on the control of key transcriptional regulators of satellite cell function, we briefly discuss early studies suggesting the UPS participates more broadly in the regulation of satellite cell stemness and regenerative capacity. Frontiers Media S.A. 2022-01-20 /pmc/articles/PMC8811165/ /pubmed/35127730 http://dx.doi.org/10.3389/fcell.2021.821839 Text en Copyright © 2022 Olguín. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Olguín, Hugo C.
The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program
title The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program
title_full The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program
title_fullStr The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program
title_full_unstemmed The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program
title_short The Gentle Side of the UPS: Ubiquitin-Proteasome System and the Regulation of the Myogenic Program
title_sort gentle side of the ups: ubiquitin-proteasome system and the regulation of the myogenic program
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811165/
https://www.ncbi.nlm.nih.gov/pubmed/35127730
http://dx.doi.org/10.3389/fcell.2021.821839
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