Cargando…

ALKBH5 Regulates SPHK1-Dependent Endothelial Cell Angiogenesis Following Ischemic Stress

BACKGROUND: Endothelial cells dysfunction has been reported in many heart diseases including acute myocardial infarction, and atherosclerosis. The molecular mechanism for endothelial dysfunction in the heart is still not clearly understood. We aimed to study the role of m(6)A RNA demethylase alkB ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumari, Rajesh, Dutta, Roshan, Ranjan, Prabhat, Suleiman, Zainab Gbongbo, Goswami, Sumanta Kumar, Li, Jing, Pal, Harish Chandra, Verma, Suresh Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811170/ https://www.ncbi.nlm.nih.gov/pubmed/35127873 http://dx.doi.org/10.3389/fcvm.2021.817304

Ejemplares similares

Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction
por: Ranjan, Prabhat, et al.
Publicado: (2021)

Cardiac Fibroblasts and Cardiac Fibrosis: Precise Role of Exosomes
por: Ranjan, Prabhat, et al.
Publicado: (2019)

ALKBH5 inhibitors as a potential treatment strategy in heart failure—inferences from gene expression profiling
por: Komal, Sumra, et al.
Publicado: (2023)

Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
por: Hatoum, Diana, et al.
Publicado: (2017)

Role of Microvessel Density and Vascular Endothelial Growth Factor in Angiogenesis of Hematological Malignancies
por: Chand, Rashika, et al.
Publicado: (2016)

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells
por: Hafizi, Redona, et al.
Publicado: (2022)

Expression and Activation of BK(Ca) Channels in Mice Protects Against Ischemia-Reperfusion Injury of Isolated Hearts by Modulating Mitochondrial Function
por: Goswami, Sumanta Kumar, et al.
Publicado: (2019)

Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
por: Bu, Yanhong, et al.
Publicado: (2021)

Human ALKBH4 Interacts with Proteins Associated with Transcription
por: Bjørnstad, Linn G., et al.
Publicado: (2012)

Inflammation and dyslipidaemia: a possible interplay between established risk factors in North Indian males with coronary artery disease
por: Goswami, Binita, et al.
Publicado: (2010)

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk
por: Schiefler, Carlotta, et al.
Publicado: (2014)

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)
por: Lu, Zhanping, et al.
Publicado: (2015)

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer
por: Datta, Arpita, et al.
Publicado: (2014)

Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A
por: Zhao, Yongchao, et al.
Publicado: (2021)

The RNA demethylase ALKBH5 promotes the progression and angiogenesis of lung cancer by regulating the stability of the LncRNA PVT1
por: Shen, Wenyi, et al.
Publicado: (2022)

Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway
por: Zhang, Hongze, et al.
Publicado: (2021)

Angiogenesis, Cancer, and Vascular Aging
por: Moriya, Junji, et al.
Publicado: (2017)

Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis
por: He, Lifan, et al.
Publicado: (2022)

SphK2 over-expression promotes osteosarcoma cell growth
por: Xu, Dawei, et al.
Publicado: (2017)

Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors
por: Geng, Shuangshuang, et al.
Publicado: (2022)

Cell fate determined by the activation balance between PKR and SPHK1
por: Qiao, Han, et al.
Publicado: (2020)

Sequence Dependent Repair of 1,N(6)-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB
por: Qi, Rui, et al.
Publicado: (2021)

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
por: Meza, Trine J., et al.
Publicado: (2012)

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells
por: He, Hanqing, et al.
Publicado: (2020)

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells
Publicado: (2022)

LncRNA ALKBH3‐AS1 enhances ALKBH3 mRNA stability to promote hepatocellular carcinoma cell proliferation and invasion
por: Lu, Qiliang, et al.
Publicado: (2022)

Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis
por: Ye, Peng, et al.
Publicado: (2022)

ALKBH4 Depletion in Mice Leads to Spermatogenic Defects
por: Nilsen, Anja, et al.
Publicado: (2014)

Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma
por: Chen, Ming-Huang, et al.
Publicado: (2015)

Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival
por: Gabriel, Tanit L., et al.
Publicado: (2017)

Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma
por: Shi, Weiwei, et al.
Publicado: (2020)

Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
por: Dai, Lan, et al.
Publicado: (2022)

SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis
por: Gu, Minghui, et al.
Publicado: (2022)

Microvesicles in Atherosclerosis and Angiogenesis: From Bench to Bedside and Reverse
por: Badimon, Lina, et al.
Publicado: (2017)

Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase
por: Li, Bowen, et al.
Publicado: (2021)

Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis
por: Miller, Bronte, et al.
Publicado: (2022)

Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis
por: Matilla, Lara, et al.
Publicado: (2022)

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro
por: Bian, Ke, et al.
Publicado: (2019)

N (6) -methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes : ALKBH5 regulated preadipocyte proliferation and differentiation
por: Zhang, Qi, et al.
Publicado: (2021)

An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma
por: Pan, Jian, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_rep2occctcbf1s9qovqipl50o6