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The Cross-Talk Between EGFR and E-Cadherin
Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major regulators of proliferation and differentiation in epithelial cells. Consistently, defects in both EGFR and E-cadherin-mediated intercellular adhesion are linked to various malignancies. These defects in either are fur...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811214/ https://www.ncbi.nlm.nih.gov/pubmed/35127732 http://dx.doi.org/10.3389/fcell.2021.828673 |
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author | Ramírez Moreno, Miguel Bulgakova, Natalia A. |
author_facet | Ramírez Moreno, Miguel Bulgakova, Natalia A. |
author_sort | Ramírez Moreno, Miguel |
collection | PubMed |
description | Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major regulators of proliferation and differentiation in epithelial cells. Consistently, defects in both EGFR and E-cadherin-mediated intercellular adhesion are linked to various malignancies. These defects in either are further exacerbated by the reciprocal interactions between the two transmembrane proteins. On the one hand, EGFR can destabilize E-cadherin adhesion by increasing E-cadherin endocytosis, modifying its interactions with cytoskeleton and decreasing its expression, thus promoting tumorigenesis. On the other hand, E-cadherin regulates EGFR localization and tunes its activity. As a result, loss and mutations of E-cadherin promote cancer cell invasion due to uncontrolled activation of EGFR, which displays enhanced surface motility and changes in endocytosis. In this minireview, we discuss the molecular and cellular mechanisms of the cross-talk between E-cadherin and EGFR, highlighting emerging evidence for the role of endocytosis in this feedback, as well as its relevance to tissue morphogenesis, homeostasis and cancer progression. |
format | Online Article Text |
id | pubmed-8811214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88112142022-02-04 The Cross-Talk Between EGFR and E-Cadherin Ramírez Moreno, Miguel Bulgakova, Natalia A. Front Cell Dev Biol Cell and Developmental Biology Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major regulators of proliferation and differentiation in epithelial cells. Consistently, defects in both EGFR and E-cadherin-mediated intercellular adhesion are linked to various malignancies. These defects in either are further exacerbated by the reciprocal interactions between the two transmembrane proteins. On the one hand, EGFR can destabilize E-cadherin adhesion by increasing E-cadherin endocytosis, modifying its interactions with cytoskeleton and decreasing its expression, thus promoting tumorigenesis. On the other hand, E-cadherin regulates EGFR localization and tunes its activity. As a result, loss and mutations of E-cadherin promote cancer cell invasion due to uncontrolled activation of EGFR, which displays enhanced surface motility and changes in endocytosis. In this minireview, we discuss the molecular and cellular mechanisms of the cross-talk between E-cadherin and EGFR, highlighting emerging evidence for the role of endocytosis in this feedback, as well as its relevance to tissue morphogenesis, homeostasis and cancer progression. Frontiers Media S.A. 2022-01-20 /pmc/articles/PMC8811214/ /pubmed/35127732 http://dx.doi.org/10.3389/fcell.2021.828673 Text en Copyright © 2022 Ramírez Moreno and Bulgakova. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Ramírez Moreno, Miguel Bulgakova, Natalia A. The Cross-Talk Between EGFR and E-Cadherin |
title | The Cross-Talk Between EGFR and E-Cadherin |
title_full | The Cross-Talk Between EGFR and E-Cadherin |
title_fullStr | The Cross-Talk Between EGFR and E-Cadherin |
title_full_unstemmed | The Cross-Talk Between EGFR and E-Cadherin |
title_short | The Cross-Talk Between EGFR and E-Cadherin |
title_sort | cross-talk between egfr and e-cadherin |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811214/ https://www.ncbi.nlm.nih.gov/pubmed/35127732 http://dx.doi.org/10.3389/fcell.2021.828673 |
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